This article shows 4 models of arrhythmias: adrenaline, barium chloride, calcium chloride and aconitine.
This combination of models allows to fully explore the wide range of antiarrhythmic drugs and to study the
mechanism of their effects. In addition, in the main parameters for study of new antiarrhythmic drugs were
selected: it has been shown that the study of blood pressure and ECG-charts, as well as variability in heart rate
period - sufficient basis for primary screening of antiarrhythmic drugs.

In experiments haloperidol's catalepsy intensity (0.5 and 1 mg/kg) of intact ovarioectomized and estrogen
ovarioectomized (at 6, 9, 12, 15, 18, 21, 24, 3 o'clock) rats were compared. Assessment of the severity of
catalepsy was performed by registration (in seconds) the duration of retention of animals given a vertical
situation in the pose of lecturer.
Circadian variations in the intensity of catalepsy in intact female rats and ovarioectomized without and
after estrogen used carried out the study found. Neuroleptic action on the dose, test time, keeping the ovaries,
estrogen levels depended. Cataleptogenic neuroleptic action after removal of the ovaries means weakened.
Estrogen used against ovarioectomy a tendency to reduce the total average daily cataleptogenic effect of
haloperidol in dose of 0.5 mg/kg and to increase in dose of 1 mg/kg caused.

Тhe results of pig tympanic membrane mobility, measured by laser autodine effect are present in artide.
Fresh specimen of pig's temporal bone were used. Some measurements were made on intact middle ear struc-
tures, on the ear specimen with imitation of adhesive process and hearing chain destruction. Asessed results are
important for further investigation of middle ear mechanics through laser autodine effect.

Experiments are executed on 10 chinchilla rabbits. The method laser Doppler's fluometry certain parameters
of microcirculation of a skin, muscles of a front abdominal wall, parietal peritoneum, the greater omentum,
mesentery a thin gut and its wall, a stomach - in the region of a fundus, a body, the greater curvature and the
pylorus. The received values of intensity of a blood-groove were analyzed by a peak-frequency spectrum and
the wavelet-analysis. It is established, that intensity of microcirculation in a wall of a stomach had the greatest
values in comparison with other investigated bodies and fabrics. Thus, the optimal from the point of view of
intensity of microcirculation were the body and greater curvature of a stomach.

For the first time the method of treatment of diabetes 2 types by means of allogenic and isogenic
cultivated stem cells from native biomodel of diabetes 2 types wich reproduce clinical manifestation of human
diabetes. The conditions which optimized treatment with stem and progenitory cells were determined. It
was demonstrated that prolong clinical effect of carbohydrate exchange and prevention of deep structural
pathogenetic violation in an internal come when stem cells used in an early stage of diabetes 2 types in high
doses or repeated application of average cells doses that allows to compensate a carbohydrate exchange for
a long time by preservation of adequate functional activity of the islets by pancreas. This method may be
considered as a preclinical stage in studing of possibilities and prospects of stem cells application in complex
treatment of diabetes of 2 types.

In the research on the rabbits influence of L-thyroxine on the activity of the protein-transporter
Р-glycoprotein (Pgp) was studied. Activity of the Pgp was studied on the pharmacokinetics of its marker
substrate fexofenadine. It was established that introduction of L-thyroxine within 14 days lead to the dose-
dependent induction of Рgp activity.

Еxam of the activity of peritoneal macrophages, NO-dependent state and mechanisms of free radical pro-
cesses in normal pregnancy and in the background of the experimental disturbance of the utero-placental
circulation (DUPC) was done with using of white rats.
With the introduction of L-NAME and DUPC in serum observed similar changes in the form of lower
levels of total nitrate and nitrite, increasing free radical processes. Activity of peritoneal macrophages varies
in the opposite way - L-NAME significantly increases her, and DUPC - decreases. When combined action of
increased production of nitric oxide formation and nitrotirozine that under these conditions plays a protective
role by providing adaptation impaired feto-placental blood flow to the needs of the fetus, the activity of mac-
rophages corresponds to the intact rats.

In vivo experiments, carried out on rats, demonstrated a possibility of degenerative changes in Pliss's
lymphosarcoma and tumor growth decrease under the influence of low-intensity laser radiation in the blue light
range (460-475 nm wavelength).

Histologic study of comparative efficacy of separate
application of osteomaterials (nanostractured
hydroxyapatite and β-tricalcium phosphate ceramics) and
combination with Traumel C
The aim of the research was histologic study of efficacy in the dynamics, combination of osteomaterials
with liquid solution of Traumel C, for healing of bone defect for the purpose of the optimization and accelera-
tion of physiologic and reparative osteogenesis.

The paper presents the author's method of visualization of the tremor - Videovizualization of the
tremor based on the use of Webcams and special computer programs to improve the efficiency of diagnosis
and control of the treatment of diseases of the central nervous system.

Ultrasonic vocalization of rats reflects various psychoemotional conditions - both positive, and negative
(alarm, fear, a stress). Prevalence of spectral power in a range of 20-30 kHz characterizes uneasiness, and the
range of 35-45 kHz corresponds to a comfortable condition.
Peptides and low-molecular proteins of a natural origin render anxiolitical, antiphobical, sedative actions
on rats. The effect is observed after a week of introduction and remains, at least, within 21 days of injections
of preparations.
The offered model of research of an emotional condition on vocalization of rats in ultrasound can be used
in nonclinical tests of preparations of similar action.

Peptides and low-molecular proteins of a natural origin influence system behaviour of rats. During
experiment the immobility systematically decreases in comparison with control, but increases «in relation
to itself». Duration of grooming for the 7th and 21st day a little decreases. Horizontal activity (locomotion)
remains almost invariable. Observable effects (decrease in duration of «dying down») are probably connected
with anxiolitical action of preparations that confirmed research of ultrasonic vocalization of rats against
introduction of the same pharmacological means.

The comparative pharmacokinetics of commonly used lipid-lowering drugs of the statin was studied by
54 healthy persons. Concentration atorvastatin, the active metabolites of simvastatin and lovastatin in plasma
by HPLC with UV-spectrophotometric detector were determined.

In this paper we describe algorithm finding the medium-line of a convolution of human brain and projection
this line on a scalp surface using Talairah's stereotaxic atlas. This algorithm can also find the thickness of a
convolution in every point of medium line.