Influence of intradermal administration of unmodified collagen on proliferative activity of skin cells of experimental animals
Abstract
Immunohistochemical method using mouse polyclonal antibodies was used to study the expression of Ki-67 antigen cell proliferation markers and phagocytes-1 growth factor (FGF-1) in mature female rats (12-13 months) with intradermal mesotherapy of unmodified bovine collagen type I, as an analogue of which we used the domestic preparation "Collost® gel". It has been established that unmodified collagen stimulates the proliferation of skin epithelial cells and hair follicles, fibroblasts, and vascular endothelium. The most pronounced expression of the cytokines studied is observed on the 7-21th day after the injection of the collagen preparation.
About the Authors
B. N. Selskaya
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
L. A. Musina
ФГБУ «Всероссийский центр глазной и пластической хирургии» Минздрава России
Russian Federation
Russian Federation
G. V. Ivanova
ООО «Проммедэко»
Russian Federation
Russian Federation
F. Kh. Kamilov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Selskaya B.N., Musina L.A., Ivanova G.V., Kamilov F.Kh. Influence of intradermal administration of unmodified collagen on proliferative activity of skin cells of experimental animals. Journal Biomed. 2018;(3):110-114. (In Russ.)
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