Analysis of the Cellular Composition of Bronchoalveolar Lavage in the Modeling and Treatment of Acute Respiratory Distress Syndrome in Biomodel Mice
https://doi.org/10.33647/2074-5982-17-3-17-22
Abstract
This article investigates changes in the cellular composition of bronchoalveolar lavage over time in the modeling of acute respiratory distress syndrome (ARDS) in mice, followed by a single administration of Leutragine. In intact animals, macrophages predominate in bronchoalveolar lavage, which is the physiological norm. When modeling ARDS, neutrophils increase. A single administration of Leutragine leads to a significant reduction in the number of neutrophils and a simultaneous increase in macrophages in 72 hours, thus bringing the cellular composition of lavage to normal.
About the Authors
O. V. Alimkina
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Oksana V. Alimkina
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye gory village, building 1
A. E. Petrenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Aleksandra Е. Petrenko
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye gory village, building 1
E. S. Savchenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Elena S. Savchenko
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye gory village, building 1
N. S. Ogneva
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Nastasya S. Ogneva
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye gory village, building 1
L. A. Taboyakova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Lidiya A. Taboyakova
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye gory village, building 1
S. V. Maksimenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Sergey V. Maksimenko, Cand. Sci. (Biol.)
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye gory village, building 1
M. M. Skripkina
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Mariya M. Skripkina
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye gory village, building 1
M. M. Borisova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Mariya M. Borisova
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye gory village, building 1
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Review
For citations:
Alimkina O.V., Petrenko A.E., Savchenko E.S., Ogneva N.S., Taboyakova L.A., Maksimenko S.V., Skripkina M.M., Borisova M.M. Analysis of the Cellular Composition of Bronchoalveolar Lavage in the Modeling and Treatment of Acute Respiratory Distress Syndrome in Biomodel Mice. Journal Biomed. 2021;17(3):17-22. (In Russ.) https://doi.org/10.33647/2074-5982-17-3-17-22
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