Pharmacological Correction of Long-Term Effects of Acute Severe Poisoning with Sodium Thiopental under Chronic Light Desynchronosis
https://doi.org/10.33647/2074-5982-17-3-23-28
Abstract
We experimentally studied the possibility of using a peptide extract from the pituitary gland of a reindeer (Rangifer tarandus) to correct the functional state of the body under the combined effect of acute severe poisoning with sodium thiopental in rats, at a dose of LD50 under long-term light desynchronosis. The research was conducted using the statistical method of two-factor analysis of variance. It was found that, under constant light, a peptide extract from the pituitary gland of a reindeer affects such parameters as diene conjugates concentration, the activity of glutathione-S-transferase and glucose-6-phosphate dehydrogenase. Under prolonged darkness, the extract under study affected the activity of glutathione-S-transferase, glutathione peroxidase and glucose-6-phosphate dehydrogenase.
About the Authors
E. G. Batotsyrenova
Golikov Research Center of Toxicology of the Federal Medical and Biological Agency of Russia; St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Ekaterina G. Batotsyrenova*, Cand. Sci. (Biol.), Assoc. Prof.
192019, Russian Federation, Saint-Petersburg, Bekhtereva Str., 1
194100, Russian Federation, Saint-Petersburg, Litovskaya Str., 2
V. A. Kashuro
Golikov Research Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Vadim A. Kashuro, Dr. Sci. (Med.), Assoc. Prof.
192019, Russian Federation, Saint-Petersburg, Bekhtereva Str., 1
A. V. Sharabanov
Scientifi c Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Andrey V. Sharabanov
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
References
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Review
For citations:
Batotsyrenova E.G., Kashuro V.A., Sharabanov A.V. Pharmacological Correction of Long-Term Effects of Acute Severe Poisoning with Sodium Thiopental under Chronic Light Desynchronosis. Journal Biomed. 2021;17(3):23-28. (In Russ.) https://doi.org/10.33647/2074-5982-17-3-23-28
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