Preview

Journal Biomed

Advanced search

Pharmacological Correction of Long-Term Effects of Acute Severe Poisoning with Sodium Thiopental under Chronic Light Desynchronosis

https://doi.org/10.33647/2074-5982-17-3-23-28

Abstract

We experimentally studied the possibility of using a peptide extract from the pituitary gland of a reindeer (Rangifer tarandus) to correct the functional state of the body under the combined effect of acute severe poisoning with sodium thiopental in rats, at a dose of LD50 under long-term light desynchronosis. The research was conducted using the statistical method of two-factor analysis of variance. It was found that, under constant light, a peptide extract from the pituitary gland of a reindeer affects such parameters as diene conjugates concentration, the activity of glutathione-S-transferase and glucose-6-phosphate dehydrogenase. Under prolonged darkness, the extract under study affected the activity of glutathione-S-transferase, glutathione peroxidase and glucose-6-phosphate dehydrogenase.

About the Authors

E. G. Batotsyrenova
Golikov Research Center of Toxicology of the Federal Medical and Biological Agency of Russia; St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia
Russian Federation

Ekaterina G. Batotsyrenova*, Cand. Sci. (Biol.), Assoc. Prof.

192019, Russian Federation, Saint-Petersburg, Bekhtereva Str., 1

194100, Russian Federation, Saint-Petersburg, Litovskaya Str., 2



V. A. Kashuro
Golikov Research Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation

Vadim A. Kashuro, Dr. Sci. (Med.), Assoc. Prof.

192019, Russian Federation, Saint-Petersburg, Bekhtereva Str., 1



A. V. Sharabanov
Scientifi c Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation

Andrey V. Sharabanov

143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1



References

1. Batocyrenova E.G., Zolotoverhaya E.A., Kashuro V.A., Sharabanov A.V. Izmenenie biohimicheskih pokazatelej v syvorotke krovi prihronicheskom svetovom desinhronoze [Changes in biochemical parameters in blood serum in chronic light desynchronosis]. Biomedicinskaya himiya [Biomedical chemistry]. 2020;66:450-455. (In Russian).

2. Stal’naya I.D. Metod opredeleniya dienovoj kon’yugacii nenasyshchennyh vysshih zhirnyh kislot [Method for determination of diene conjugation of unsaturated higher fatty acids]. Sovremennye metody v biohimii [Modern methods in biochemistry]. Ed. by V.N. Orekhovich. Moscow: Meditsina Publ., 1977:63-64. (In Russian).

3. Ellman G.L. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics. 1959;82(1):70-77.

4. Habig W.H. Assay for differentiation of glutathione S-transferases. Methods in Enzymology. 1981;77:398-405.

5. Reddy A.B., Rey G. Interplay between cellular redox oscillation. Diabetes, Obesity and Metabolism. 2015;17(1):55-64.

6. Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Analytical Biochemistry. 1978;86(1):271-278.


Review

For citations:


Batotsyrenova E.G., Kashuro V.A., Sharabanov A.V. Pharmacological Correction of Long-Term Effects of Acute Severe Poisoning with Sodium Thiopental under Chronic Light Desynchronosis. Journal Biomed. 2021;17(3):23-28. (In Russ.) https://doi.org/10.33647/2074-5982-17-3-23-28

Views: 465


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-5982 (Print)
ISSN 2713-0428 (Online)