Pharmacological Correction of Long-Term Effects of Acute Severe Poisoning with Sodium Thiopental under Chronic Light Desynchronosis
https://doi.org/10.33647/2074-5982-17-3-23-28
Abstract
We experimentally studied the possibility of using a peptide extract from the pituitary gland of a reindeer (Rangifer tarandus) to correct the functional state of the body under the combined effect of acute severe poisoning with sodium thiopental in rats, at a dose of LD50 under long-term light desynchronosis. The research was conducted using the statistical method of two-factor analysis of variance. It was found that, under constant light, a peptide extract from the pituitary gland of a reindeer affects such parameters as diene conjugates concentration, the activity of glutathione-S-transferase and glucose-6-phosphate dehydrogenase. Under prolonged darkness, the extract under study affected the activity of glutathione-S-transferase, glutathione peroxidase and glucose-6-phosphate dehydrogenase.
About the Authors
E. G. BatotsyrenovaRussian Federation
Ekaterina G. Batotsyrenova*, Cand. Sci. (Biol.), Assoc. Prof.
192019, Russian Federation, Saint-Petersburg, Bekhtereva Str., 1
194100, Russian Federation, Saint-Petersburg, Litovskaya Str., 2
V. A. Kashuro
Russian Federation
Vadim A. Kashuro, Dr. Sci. (Med.), Assoc. Prof.
192019, Russian Federation, Saint-Petersburg, Bekhtereva Str., 1
A. V. Sharabanov
Russian Federation
Andrey V. Sharabanov
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
References
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Review
For citations:
Batotsyrenova E.G., Kashuro V.A., Sharabanov A.V. Pharmacological Correction of Long-Term Effects of Acute Severe Poisoning with Sodium Thiopental under Chronic Light Desynchronosis. Journal Biomed. 2021;17(3):23-28. (In Russ.) https://doi.org/10.33647/2074-5982-17-3-23-28