Exhausting Physical Exercise Causes a Multiple Increase in the Transcription of HMGB1 Gene in Mini Pigs’ Lymphocytes
https://doi.org/10.33647/2074-5982-18-1-22-31
Abstract
It is shown for the first time that debilitating physical activity causes a short-term multiple increase in the transcription of the HMGB1 gene in the cells of the leukocyte blood fraction (lymphocytes) of mini pigs and a statistically significant increase in the level of leukocytes. At the same time, other morphological parameters of the blood remain unchanged due to an increase in the number of neutrophils in the post-exercise period (up to 6 hours inclusive). Neutrophils can be considered both as a marker for investigating the effect of limiting physical activity on the processes associated with recovery and as a potential damaging factor. Lymphocytes are presumably the source of HMGB1 during short-term debilitating physical activity. The revealed increase in HMGB1 gene transcription is of a compensatory nature and is aimed at restoring the HMGB1 lymphocytic protein pool in the post-exercise period. Leukocyte HMGB1 can play the role of a damaging factor or a regeneration factor depending on the type and duration of physical activity, given its specific role in accelerating the formation of new muscle fibers, increasing their size and vascularization of muscle tissue.
Keywords
About the Authors
V. N. Karkischenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Vladislav N. Karkischenko, Dr. Sci. (Med.), Prof.
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
I. A. Pomytkin
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Igor A. Pomytkin, Cand. Sci. (Chem.)
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
N. V. Petrova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Nataliya V. Petrova
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
N. V. Stankova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Nataliia V. Stankova, Cand. Sci. (Biol.)
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
O. V. Alimkina
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Oksana V. Alimkina
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
Yu. V. Fokin
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Yuriy V. Fokin, Cand. Sci. (Biol.)
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
A. M. Zubaliy
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Anastasiya M. Zubaliy
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
N. A. Laryushina
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Nadezhda A. Laryushina
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
I. A. Vasil’eva
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Irina A. Vasil’eva
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
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Review
For citations:
Karkischenko V.N., Pomytkin I.A., Petrova N.V., Stankova N.V., Alimkina O.V., Fokin Yu.V., Zubaliy A.M., Laryushina N.A., Vasil’eva I.A. Exhausting Physical Exercise Causes a Multiple Increase in the Transcription of HMGB1 Gene in Mini Pigs’ Lymphocytes. Journal Biomed. 2022;18(1):22-31. (In Russ.) https://doi.org/10.33647/2074-5982-18-1-22-31
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