Effects of Melanocortins on the Intensity of Lipid Peroxidation in Immunocompetent Organs of Male Rats under Informational Stress
https://doi.org/10.33647/2074-5982-18-1-67-74
Abstract
In this work, we investigate effects of neuropeptides – analogues of a fragment of adrenocorticotropic hormone – Semax (a registered drug) and ACTH (6-9)-Pro-Gly-Pro (a new compound) – on the intensity of free radical oxidation processes in the immunocompetent organs of male rats exposed to informational stress. The simulated informational stress was found to stimulate peroxidation processes in the immunocompetent organs: thymus and spleen. The decrease in the level of TBK-reactive products in the homogenates of the spleen and thymus tissue of male rats, as well as the rate of lipid peroxidation, determine the protective effect of the studied melanocortins under the conditions of simulated informational stress.
About the Authors
A. L. Yasenyavskaya
Astrakhan State Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Anna L. Yasenyavskaya, Cand. Sci. (Med.), Assoc. Prof.,
414000, Astrakhan, Bakinskaya Str., 121
M. A. Samotrueva
Astrakhan State Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Marina A. Samotrueva, Dr. Sci. (Med.), Prof.
414000, Astrakhan, Bakinskaya Str., 121
G. N. Genatullina
Astrakhan State Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Guzel N. Genatullina, Cand. Sci. (Biol.)
414000, Astrakhan, Bakinskaya Str., 121
A. O. Lendov
Children’s City Polyclinic No. 1
Russian Federation
Russian Federation
Andrey O. Lendov
414000, Astrakhan, Kirova Str., 47
L. A. Andreeva
Institute of Molecular Genetics of National Research Center “Kurchatov Institute”
Russian Federation
Russian Federation
Lyudmila A. Andreeva
123182, Moscow, Academika Kurchatova Square, 2
N. F. Myasoedov
Institute of Molecular Genetics of National Research Center “Kurchatov Institute”
Russian Federation
Russian Federation
Nikolay F. Myasoedov, Dr. Sci. (Chem.), Prof.
123182, Moscow, Academika Kurchatova Square, 2
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Review
For citations:
Yasenyavskaya A.L., Samotrueva M.A., Genatullina G.N., Lendov A.O., Andreeva L.A., Myasoedov N.F. Effects of Melanocortins on the Intensity of Lipid Peroxidation in Immunocompetent Organs of Male Rats under Informational Stress. Journal Biomed. 2022;18(1):67-74. (In Russ.) https://doi.org/10.33647/2074-5982-18-1-67-74
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