EVALUATION OF THE CEREBROPROTECTIVE ACTIVITY OF NOOTROPICS IN COMBINATION WITH MELAXEN BY A MORPHOLOGICAL ANALYSIS USING A MODEL OF BRAIN ISCHEMIA IN RATS
https://doi.org/10.33647/2074-5982-15-3-41-48
Abstract
The cerebroprotective activity of nootropics in combination with melaxen (melatonin containing drug) was investigated by a comprehensive morphological analysis using an experimental model of acute cerebral ischemia in rats. According to the obtained data, a preventive use of vinpocetine in combination with melaxen signifi cantly reduces the degree of lethality among experimental animals and the severity of ischemic brain damage. A suggestion is made about the potential feasibility of melatonin-containing drugs for increasing the effi cacy of neuroprotection in cerebral ischemia.
About the Authors
E. V. Gantsgorn
Rostov State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Cand. Sci. (Med.),
344022, Rostov-on-Don, Nakhichevanskyj lane, 29
D. P. Khloponin
Rostov State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. Sci. (Med.), Assoc. Prof.,
344022, Rostov-on-Don, Nakhichevanskyj lane, 29
P. A. Khloponin
Rostov State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. Sci. (Med.), Prof.,
344022, Rostov-on-Don, Nakhichevanskyj lane, 29
Yu. S. Maklyakov
Rostov State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. Sci. (Med.), Prof.,
344022, Rostov-on-Don, Nakhichevanskyj lane, 29
References
1. Arushanyan E.B. Zashchitnaya rol’ melatonina pri narusheniyah mozgovogo krovoobrashcheniya [The protective role of melatonin in disorders of cerebral circulation]. Russkij medicinskij zhurnal (Nevrologiya) [Rus. Med. J. (Neurology)]. 2010;18(6):57–61. (In Russian).
2. Gantsgorn E.V., Kolmakova T.S., Maklyakov Yu.S., Khloponin D.P. Ocenka dejstviya cerebroprotektornyh sredstv metodom hemilyuminescentnogo analiza antioksidantnyh svojstv krovi na modeli global’noj ishemii golovnogo mozga [Evaluation of the action of cerebroprotective drugs by chemiluminescent analysis of the antioxidant properties of blood on the model of global cerebral ischemia]. Biofarmacevticheskij zhurnal [Biopharmaceutical J.]. 2012;4(2):14–20. (In Russian).
3. Gantsgorn E.V., Maklyakov Yu.S., Khloponin D.P. Kolichestvennyj farmako-EEG analiz aktivnosti nootropov i ih kombinacij s melaksenom pri global’noj ishemii golovnogo mozga u krys [Quantitative pharmaco-EEG analysis of the activity of nootropics and their combinations with mela xen in global cerebral ischemia in rats]. Biomedicine. 2015;3:87–94. (In Russian).
4. Gantsgorn E.V., Khloponin D.P., Maklyakov Yu.S. Analiz vyzhivaemosti i chastotno-prostranstvennogo raspredeleniya elektroencefalografi cheskih pokazatelej krys pri global’noj ishemii golovnogo mozga [Analysis of the survival and frequency-spatial distribution of electroencephalographic indices of rats with global cerebral ischemia]. Kubanskij nauchnyj medicinskij vestnik [Kuban Scientifi c and Medical Bulletin]. 2017;2:43–49. (In Russian).
5. Zaharov V.V., Kalimeeva E.Yu. Nejroprotektivnaya terapiya v ostrom i vosstanovitel’nom periodah ishemicheskogo insul’ta [Neuroprotective therapy in acute and recovery periods of ischemic stroke]. Effective pharmacotherapy. 2017;33:10–14. (In Russian).
6. Samorodskaya I.V., Zajrat’yanc O.V., Perhov V.I., Andreev E.M., Vajsman D.Sh. Dinamika pokazatelej smertnosti naseleniya ot ostrogo narusheniya mozgovogo krovoobrashcheniya v Rossii i SShA za 15-letnij period [Dynamics of mortality indicators of the population from acute cerebrovascular accident in Russia and the United States over a 15-year period]. Arch. Pathology. 2018;2:30–37. (In Russian).
7. Chazova I.E., Oshchepkova E.V. Bor’ba s serdechno-sosudistymi zabolevaniyami: problemy i puti ih resheniya na sovremennom etape [Fight against cardiovascular diseases: problems and ways of solving them at the present stage] Vestnik Roszdravnadzora [Bulletin of Roszdravnadzor]. 2015;5:7–10. (In Russian).
8. Andrew N.E., Thrift A.G., Cadilhac D.A. The prevalence, impact and economic implications of atrial fi brillation in stroke: what progress has been made? Neuroepidemiology. 2013;40:227–239.
9. Cardinali D.P. Melatonin, aging, and Alzheimer’s disease. In: Principles and practice of geriatric sleep medicine. Cambridge University Press, 2010. 448 p.
10. Reynolds E.S. The use of lead citrate at high pH as an electron opaque stain in electron microscopy. J. Cell. Biol. 1963;17:208–212.
11. Song T., Pan Y., Chen R. Is there a correlation between socioeconomic disparity and functional outcome after acute ischemic stroke? PLoS One. 2017;12. ID e0181196.
12. Watson M.L. Staining of tissue sections for electron microscopy with heavy metals. J. Biophys. Biochem. Cytol. 1958;4:475–478.
13. Watson M.L. Staining of tissue sections for electron microscopy with heavy metals: II. Application of solutions containing lead and barium. J. Biophys. Biochem. Cytol. 1958;4:727–730.
14. Watson R.R. Melatonin in the promotion of health. 2nd еd. Taylor & Francis Group LLC., 2012. 582 p.
Review
For citations:
Gantsgorn E.V., Khloponin D.P., Khloponin P.A., Maklyakov Yu.S. EVALUATION OF THE CEREBROPROTECTIVE ACTIVITY OF NOOTROPICS IN COMBINATION WITH MELAXEN BY A MORPHOLOGICAL ANALYSIS USING A MODEL OF BRAIN ISCHEMIA IN RATS. Journal Biomed. 2019;(3):41-48. (In Russ.) https://doi.org/10.33647/2074-5982-15-3-41-48
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