Study into the Efficacy of the Epophen Substance in Normobaric Hypoxia
https://doi.org/10.33647/2074-5982-19-2-45-53
Abstract
Hypoxia is associated with reduced oxygen levels in the body, individual organs, or tissues. Hypoxia is the most common cause of cell damage, emerging under a lack of oxygen in the inhaled air, blood (hypoxemia), or tissues (violations of tissue respiration). When the strength or duration of hypoxic exposure exceeds the adaptive capabilities of the body, an organ, or a tissue, irreversible changes may develop. Resistance to hypoxia can be enhanced by pharmacological agents that improve oxygen delivery and/or the effectiveness of its use. This study was conducted to determine the antihypoxic effect of the Epophen drug. Epophen was found to exhibit a pronounced antihypoxic effect, with the efficacy varying from 24 to 89% depending on the drug dose and hypoxia type.
About the Authors
K. S. Ostrenko
All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — Branch of the Federal Scientific Center of Animal Husbandry — The All-Russian Institute of Animal Husbandry named after Academician L.K. Ernst
Russian Federation
Russian Federation
Konstantin S. Ostrenko - Dr. Sci. (Biol.), All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — Branch of the Federal Scientific Center of Animal Husbandry — The All-Russian Institute of Animal Husbandry named after Academician L.K. Ernst.
249013, Kaluga Region, Borovsk, Institut Village
A. N. Ovcharova
All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — Branch of the Federal Scientific Center of Animal Husbandry — The All-Russian Institute of Animal Husbandry named after Academician L.K. Ernst
Russian Federation
Russian Federation
Anastasia N. Ovcharova - Cand. Sci. (Biol.), All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — Branch of the Federal Scientific Center of Animal Husbandry — The All-Russian Institute of Animal Husbandry named after Academician L.K. Ernst.
249013, Kaluga Region, Borovsk, Institut Village
O. P. Yegorova
Scientific and Production Company “IGLESIA”
Russian Federation
Russian Federation
Olga P. Yegorova.
115516, Moscow, Bakinskaya Str., 18, Sq. 10
References
1. Allayarov R.K., Stepanova N.N., Morgunov G.I., Kamzolova S.V. Perspektivy razrabotki novykh preparatov na osnove biosinteticheskikh organicheskikh kislot dlya profilaktiki i lecheniya gipoksii v usloviyakh dlitel'nykh kosmicheskikh ekspeditsiy [Prospects for the development of new drugs based on biosynthetic organic acids for the prevention and treatment of hypoxia in long-term space missions]. Biznes v zakone. Ekonomiko-yuridicheskiy zhurnal [Business in law. Economic and legal journal]. 2016;6:168-171. (In Russian).
2. Evseeva M.A., Evseev A.V., Pravdivcev V.A., Shabanov P.D. Mekhanizmy razvitiya ostroy gipoksii i puti ee farmakologicheskoy korrektsii [Mechanisms of development of acute hypoxia and ways of its pharmacological correction]. Obzory po klinicheskoy farmakologii i lekarstvennoy terapii [Reviews of clinical pharmacology and drug therapy]. 2008;6(1):3-25. (In Russian).
3. Zamoshchina T.A., Gostyuhina A.A., Zajcev K.V., Svetlik M.V., Zhukova O.B. Vliyanie meksidola na fizicheskuyu rabotosposobnost' i uroven' laktata v krovi krys v usloviyakh svetovykh desinkhronozov [Influence of mexidol on physical performance and lactate level in the blood of rats under conditions of light desynchronosis]. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova [S.S. Korsakov Journal of Neurology and Psychiatry]. 2018;118(11):82-86. (In Russian). DOI: 10.17116/jnevro201811811182.
4. Karkischenko V.N., Karkischenko N.N., Shustov E.B., Berzin I.A., Fokin Yu.V., Alimkina O.V. Osobennosti interpretatsii pokazateley rabotosposobnosti laboratornykh zhivotnykh po plavatel'nym testam s nagruzkoy [Peculiarities of interpretation of performance indicators of laboratory animals in swimming tests with load]. Biomeditsina [Journal Biomed]. 2016;4:34-46. (In Russian).
5. Klinicheskaya laboratornaya diagnostika. T. 2. Natsional'noe rukovodstvo [Clinical laboratory diagnostics. Vol. 2. National guidelines]. Ed. by V.V. Dolgov. Moscow: GEOTAR-Media Publ.; 2012. (In Russian).
6. Malkova Ya.G., Kal'chenko G.P. Ispol'zovanie razlichnykh modeley gipoksii v eksperimental'noy farmakologii [The use of various models of hypoxia in experimental pharmacology]. Molodoy uchenyy [Young scientist]. 2010;3(14):318-319. (In Russian).
7. Medik V.A., Tokmachev M.S., Fishman B.B. Statistika v meditsine i biologii [Statistics in medicine and biology]. Moscow: Meditsina Publ., 2001. (In Russian).
8. Nagibovich O.A., Uhovskij D.M., Zhekalov A.N., Tkachuk N.A., Arzhavkina L.G., Bogdanova E.G., Murzina E.V., Belikova T.M. Mekhanizmy gipoksii v arkticheskoy zone Rossiyskoy Federatsii [Mechanisms of hypoxia in the Arctic zone of the Russian Federation]. Vestnik Rossiyskoy voenno-meditsinskoy akademii [Bulletin of the Russian Military Medical Academy]. 2016;2(54):202-205. (In Russian).
9. Prikaz Minzdravsocrazvitiya Rossii № 750н ot 26.08.2010. «Ob utverzhdenii pravil provedeniya ekspertizy lekarstvennyh sredstv dlya medicinskogo primeneniya i formy zaklyucheniya komissii ekspertov» [Order of the Ministry of Health and Social Development of Russia No. 750н dated 26.08.2010 “On approval of the rules for the examination of medicines for medical use and the form of the conclusion of the commission of experts”]. (In Russian).
10. Prikaz Minzdravsocrazvitiya Rossii № 708н ot 23.08.2010 «Ob utverzhdenii pravil laboratornoj praktiki» [Order of the Ministry of Health and Social Development of Russia No. 708н dated 23.08.2010 “On approval of the rules of laboratory practice”]. (In Russian).
11. Rukovodstvo po eksperimental'nomu (doklinicheskomu) izucheniyu novyh farmakologicheskih veshchestv [Guidelines for the experimental (preclinical) study of new pharmacological substances]. Ed. by R.U. Khabriev. Moscow: Meditsina Publ., 2005. (In Russian).
12. Ryabov G.A. Gipoksiya kriticheskikh sostoyaniy [Hypoxia of critical conditions]. Moscow: Meditsina Publ.; 1998:89-96. (In Russian).
13. Shustov E.B., Karkischenko N.N., Karkischenko V.N., Kapanadze G.D., Stankova N.V., Revyakin A.O., Matveyenko E.L., Kim A.E., Shulenin N.S. Gipoksiya fizicheskoy nagruzki: izuchenie u cheloveka i laboratornykh zhivotnykh [Exercise hypoxia: A study in humans and laboratory animals]. Biomeditsina [Journal Biomed]. 2014;4:4-16. (In Russian).
Review
For citations:
Ostrenko K.S., Ovcharova A.N., Yegorova O.P. Study into the Efficacy of the Epophen Substance in Normobaric Hypoxia. Journal Biomed. 2023;19(2):45-53. (In Russ.) https://doi.org/10.33647/2074-5982-19-2-45-53
Views:
408
Email this article 
