Modern Views and Analysis of Promising Approaches to the Treatment of Melanoma
https://doi.org/10.33647/2074-5982-19-3-47-52
Abstract
Melanoma is a malignant tumor that can rapidly develop resistance to treatment because of its high mutational activity. The introduction of tyrosine kinase receptor inhibitors (BRAF, MEK) and cytotoxic T lymphocyte antigen/receptor inhibitors (CTLA4, PD-1) into clinical practice has led to an increase in patient survival rates. In in vitro studies, combining PIK3 and MEK inhibitors demonstrate a pronounced reduction in tumor cell growth. The phenomenon of synthetic lethality is also promising, allowing the high mutational load of melanoma to be used as a tool for the development of more effective drugs.
About the Authors
A. V. Safronenko
Rostov State Medical University of the Ministry of Health Care of Russia
Россия
Россия
Andrey V. Safronenko, Dr. Sci. (Med.), Prof.
344037, Rostov-on-Don, Nahichevansky Ave., 29
O. M. Kudelina
Rostov State Medical University of the Ministry of Health Care of Russia
Россия
Россия
Oksana M. Kudelina, Cand. Sci. (Med.)
344037, Rostov-on-Don, Nahichevansky Ave., 29
E. V. Gantsgorn
Rostov State Medical University of the Ministry of Health Care of Russia
Россия
Россия
Elena V. Gantsgorn, Cand. Sci. (Med.), Assoc. Prof
344037, Rostov-on-Don, Nahichevansky Ave., 29
M. Kh.-B. Buraeva
Rostov State Medical University of the Ministry of Health Care of Russia
Россия
Россия
Maret Kh.-B. Burayeva
344037, Rostov-on-Don, Nahichevansky Ave., 29
M. Kh.-B. Buraeva
National Medical Research Centre for Oncology of the Ministry of Health Care of Russia
Россия
Россия
Malika Kh.-B. Burayeva, Resident
344037, Rostov-on-Don, 14-th Line Str., 63
A. A. Miteneva
Rostov State Medical University of the Ministry of Health Care of Russia
Россия
Россия
Anna A. Miteneva
344037, Rostov-on-Don, Nahichevansky Ave., 29
L. R. Shvelidze
Rostov State Medical University of the Ministry of Health Care of Russia
Россия
Россия
Luka R. Shvelidze
344037, Rostov-on-Don, Nahichevansky Ave., 29
D. A. Kalmykova
Rostov State Medical University of the Ministry of Health Care of Russia
Россия
Россия
Darya A. Kalmykova
344037, Rostov-on-Don, Nahichevansky Ave., 29
A. A. Ilyina
Rostov State Medical University of the Ministry of Health Care of Russia
Россия
Россия
Alisa A. Ilyina
344037, Rostov-on-Don, Nahichevansky Ave., 29
V. Z. Lachinov
Rostov State Medical University of the Ministry of Health Care of Russia
Россия
Россия
Vadim Z. Lachinov
344037, Rostov-on-Don, Nahichevansky Ave., 29
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For citations:
Safronenko A.V., Kudelina O.M., Gantsgorn E.V., Buraeva M.Kh., Buraeva M.Kh., Miteneva A.A., Shvelidze L.R., Kalmykova D.A., Ilyina A.A., Lachinov V.Z. Modern Views and Analysis of Promising Approaches to the Treatment of Melanoma. Journal Biomed. 2023;19(3):47-52. (In Russ.) https://doi.org/10.33647/2074-5982-19-3-47-52
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