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Experimental Model to Substantiate the Application of New Biologically Active Substances for Correcting Physiological Processes and Functions

https://doi.org/10.33647/2074-5982-19-3-66-70

Abstract

In this research, we aim to develop and investigate nanostructured clathrate complexes of 20-hydroxyecdysterone, a rhodanine derivative of 3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one, with various clathrate formers, such as arabinogalactan and β-cyclodextrin. For the first time, an experimental model is proposed to justify their use for the correction of physiological processes and functions, both in normal and pathologic conditions in the animal body. The results obtained substantiate the possibility of regulating metabolic processes by activating signaling pathways associated with cell proliferation.

About the Authors

K. T. Erimbetov
Research Technological Center “Preventive Information Medicine”
Russian Federation

Kenes T. Erimbetov, Dr. Sci. (Biol.)

249030, Kaluga Region, Obninsk, Kievskoe Highway, 3, Building 2, Office 8



R. A. Zemlyanoy
Research Technological Center “Preventive Information Medicine”
Russian Federation

Ruslan A. Zemlyanoy

249030, Kaluga Region, Obninsk, Kievskoe Highway, 3, Building 2, Office 8



A. V. Fedorova
Medical Radiological Research Center named after A.F. Tsyb — Branch of the National Medical Research Center for Radiology of the Ministry of Health Care of Russia
Russian Federation

Alena V. Fedorova

249036, Kaluga Region, Obninsk, Koroleva Str., 4



O. V. Obvintseva
All-Russian Research Institute of Physiology, Biochemistry and Nutrition of Animals — Branch of the Federal Research Center for Animal Husbandry — All-Russian Institute of Animal Husbandry named after L.K. Ernst
Russian Federation

Olga V. Obvintseva, Cand. Sci. (Biol.)

142132, Moscow Region, Podolsk, Dubrovitsy Village, 60



References

1. Еримбетов К.Т., Обвинцева О.В., Соловьева А.Г., Федорова А.В., Земляной Р.А. Сигнальные пути и факторы регуляции синтеза и распада белков в скелетных мышцах (обзор). Проблемы биологии продуктивных животных. 2020;1:24–33. [Erimbetov K.T., Obvintseva O.V., Solovieva A.G., Fedorova A.V., Zemlyanoy R.A. Signal'nye puti i faktory regulyatsii sinteza i raspada belkov v skeletnykh myshtsakh (obzor) [Signaling pathways and factors regulating the synthesis and breakdown of proteins in skeletal muscles (review)]. Problemy biologii produktivnykh zhivotnykh [Problems of productive animals biology]. 2020;1:24–33. (In Russian)]. DOI: 10.25687/1996-6733.prodanimbiol.2020.1.24-33.

2. Anthony T.G. Mechanisms of protein balance in skeletal muscle. Domest. Anim. Endocrinol. 2016;56(Suppl.): 23–32. DOI: 10.1016/j.domaniend. 2016.02.012.

3. Davis T.A., Fiorotto M.L., Suryawan A. Bolus vs. continuous feeding to optimize anabolism in neonates. Curr. Opin. Clin. Nutr. Metabol. Care. 2015;18(1):102– 108. DOI: 10.1097/MCO.0000000000000128.

4. Davis T.A., Suryawan A., Orellana R.A., Fiorotto M.L., Burrin D.G. Amino acids and insulin are regulators of muscle protein synthesis in neonatal pigs. Animal. 2010;4(11):1790–1796. DOI: 10.1017/ S1751731110000984.

5. Davis T.A., Suryawan A., Orellana R.A., Nguyen H.V., Fiorotto M.L. Postnatal ontogeny of skeletal muscle protein synthesis in pigs. J. Anim. Sci. 2008;86(14 Suppl.):13–18. DOI: 10.2527/jas.2007-0419.

6. Montenegro M.C., Peraza P., Balemian N., Carballo C., Barlocco N., Barrios P.G., Mernies B., Saadoun A., Castro G., Guimarães S.F., Llambí S. Gene expression analysis by RNA-sequencing of Longissimus dorsi muscle of pigs fed diets with differing lipid contents. Genet. Mol. Res. 2019;18(4):gmr183097. DOI: 10.4238/gmr18307.


Review

For citations:


Erimbetov K.T., Zemlyanoy R.A., Fedorova A.V., Obvintseva O.V. Experimental Model to Substantiate the Application of New Biologically Active Substances for Correcting Physiological Processes and Functions. Journal Biomed. 2023;19(3):66-70. (In Russ.) https://doi.org/10.33647/2074-5982-19-3-66-70

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ISSN 2074-5982 (Print)
ISSN 2713-0428 (Online)