Experimental Model to Substantiate the Application of New Biologically Active Substances for Correcting Physiological Processes and Functions
https://doi.org/10.33647/2074-5982-19-3-66-70
Abstract
In this research, we aim to develop and investigate nanostructured clathrate complexes of 20-hydroxyecdysterone, a rhodanine derivative of 3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one, with various clathrate formers, such as arabinogalactan and β-cyclodextrin. For the first time, an experimental model is proposed to justify their use for the correction of physiological processes and functions, both in normal and pathologic conditions in the animal body. The results obtained substantiate the possibility of regulating metabolic processes by activating signaling pathways associated with cell proliferation.
About the Authors
K. T. Erimbetov
Research Technological Center “Preventive Information Medicine”
Russian Federation
Russian Federation
Kenes T. Erimbetov, Dr. Sci. (Biol.)
249030, Kaluga Region, Obninsk, Kievskoe Highway, 3, Building 2, Office 8
R. A. Zemlyanoy
Research Technological Center “Preventive Information Medicine”
Russian Federation
Russian Federation
Ruslan A. Zemlyanoy
249030, Kaluga Region, Obninsk, Kievskoe Highway, 3, Building 2, Office 8
A. V. Fedorova
Medical Radiological Research Center named after A.F. Tsyb — Branch of the National Medical Research Center for Radiology of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Alena V. Fedorova
249036, Kaluga Region, Obninsk, Koroleva Str., 4
O. V. Obvintseva
All-Russian Research Institute of Physiology, Biochemistry and Nutrition of Animals — Branch of the Federal Research Center for Animal Husbandry — All-Russian Institute of Animal Husbandry named after L.K. Ernst
Russian Federation
Russian Federation
Olga V. Obvintseva, Cand. Sci. (Biol.)
142132, Moscow Region, Podolsk, Dubrovitsy Village, 60
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Review
For citations:
Erimbetov K.T., Zemlyanoy R.A., Fedorova A.V., Obvintseva O.V. Experimental Model to Substantiate the Application of New Biologically Active Substances for Correcting Physiological Processes and Functions. Journal Biomed. 2023;19(3):66-70. (In Russ.) https://doi.org/10.33647/2074-5982-19-3-66-70
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