Structural Changes in the Kidneys of Rats with Different Adrenoreactivity in Modeled Unilateral Ureteral Obstruction
https://doi.org/10.33647/2074-5982-20-4-48-58
Abstract
The dependence of adaptive and compensatory reactions of the kidneys on the sensitivity of β2-adrenoreceptors was studied in a rat model of unilateral ureteral obstruction. The kidney morphology was examined after 24, 48, and 72 hours of obstruction or 30 days after its termination in rats with different adrenoreactivity. In hyperreactive rats, destruction of the tubules, reduced proportion of blood vessels, and leukocyte infiltration of the interstitium were predominant. However, vacuole dystrophy of the tubular epithelium and hemostasis in the medullary vessels prevailed in hyporeactive rats. Following 30 days after 72 h of obstruction, changes in the kidneys of hyper- and hyporeactive rats were more distinct than in normoreactive ones. Thus, the response of the kidneys to ureteral obstruction depends on the β2-adrenoreceptor sensitivity. Importantly both increased and decreased adrenoreactivity deteriorates the recovery.
About the Authors
E. V. Chereshneva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Elizaveta V. Chereshneva, Cand. Sci. (Med.), Assoc. Prof.
119048, Moscow, Trubetskaya Str., 8, building 2
D. A. Tsomartova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Dibakhan A. Tsomartova, Dr. Sci. (Med.), Assoc. Prof.
119048, Moscow, Trubetskaya Str., 8, building 2
M. Yu. Ivanova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Marina Yu. Ivanova, Cand. Sci. (Med.), Assoc. Prof.
119048, Moscow, Trubetskaya Str., 8, building 2
E. S. Tsomartova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Elina S. Tsomartova, Cand. Sci. (Med.)
119048, Moscow, Trubetskaya Str., 8, building 2
T. A Lomanovskaya
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Tatyana A. Lomanovskaya, Cand. Sci. (Med.)
119048, Moscow, Trubetskaya Str., 8, building 2
M. S. Pavlova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Mariya S. Pavlova
119048, Moscow, Trubetskaya Str., 8, building 2
E. F. Barinov
Donetsk State Medical University named after M. Gorky
Russian Federation
Russian Federation
Eduard F. Barinov, Dr. Sci. (Med.), Prof.
283003, Donetsk People's Republic, Donetsk, Ilyicha Ave., 16
O. V. Payushina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Olga V. Payushina, Dr. Sci. (Biol.), Assoc. Prof.
119048, Moscow, Trubetskaya Str., 8, building 2
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Review
For citations:
Chereshneva E.V., Tsomartova D.A., Ivanova M.Yu., Tsomartova E.S., Lomanovskaya T.A., Pavlova M.S., Barinov E.F., Payushina O.V. Structural Changes in the Kidneys of Rats with Different Adrenoreactivity in Modeled Unilateral Ureteral Obstruction. Journal Biomed. 2024;20(4):48-58. (In Russ.) https://doi.org/10.33647/2074-5982-20-4-48-58
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