Mechanism Behind Anti-Inflammatory Effect of 5-Oxypyrimidine Derivative SNK-578 (2-Isobutyl-4,6-Dimethyl-5-Oxypyrimidine Hydrochloride)
https://doi.org/10.33647/2074-5982-22-1-99-104
Abstract
Literature data indicate that cyclooxygenase-2 (COX-2) expression in tumor cells leads to excessive production of prostaglandin E2 (PGE2), which accelerates carcinogenesis and reduces survival rates by creating an immunosuppressive tumor microenvironment. The present study evaluated the ability of the 5-oxypyrimidine derivative SNK-578 to inhibit COX isoform activity in a cell-free system. The analysis of COX-1 and COX-2 activities revealed that SNK-578 is a non-selective inhibitor of both iso-forms. These results suggest that COX-dependent anti-inflammatory activity is one of the mechanisms underlying the multicomponent antitumor effect of 5-oxypyrimidine derivatives.
About the Authors
R. V. Zhurikov
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Ruslan V. Zhurikov
125315, Russian Federation, Moscow, Baltiyskaya Str., 8
L. F. Zainullina
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Liana F. Zainullina, Cand. Sci. (Biol.),
125315, Russian Federation, Moscow, Baltiyskaya Str., 8
L. P. Kovalenko
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Larisa P. Kovalenko, Dr. Sci. (Biol.)
125315, Russian Federation, Moscow, Baltiyskaya Str., 8
L. G. Kolik
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Larisa G. Kolik, Dr. Sci. (Biol.), Prof.,
125315, Russian Federation, Moscow, Baltiyskaya Str., 8
V. L. Dorofeev
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Dorofeev L. Vladimir, Dr. Sci. (Pharm.), Prof.,
125315, Russian Federation, Moscow, Baltiyskaya Str., 8
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Review
For citations:
Zhurikov R.V., Zainullina L.F., Kovalenko L.P., Kolik L.G., Dorofeev V.L. Mechanism Behind Anti-Inflammatory Effect of 5-Oxypyrimidine Derivative SNK-578 (2-Isobutyl-4,6-Dimethyl-5-Oxypyrimidine Hydrochloride). Journal Biomed. 2026;22(1):99-104. (In Russ.) https://doi.org/10.33647/2074-5982-22-1-99-104
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