Effect of metoprolol and bisoprolol on the course of experimental bronchial asthma
Abstract
In this article were shown the results of monoand combination therapy with antiinflammatory .-blockers in rats with experimental bronchial asthma. It is observed, morphological changes in the lungs, revealed changes in the density of .-adrenergic receptors by the action of basis antiinflammatory therapy. It was found that the selective .-blockers in animals with experimental asthma, inhalation or oral administration does not increase the severity of inflammatory change equations in the broncho-pulmonary tree. On top of basis therapy of bronchial asthma, with the additional use of .-adrenoblockers density of .-adrenergic receptors does not decrease, but also has a tendency to increase. Thus, it seems perspective to further researching the possibility of application, efficacy and safety of combined use of .-adrenoblockers with basic treatment of asthma, in patients with asthma and in patients with combined cardio-pulmonary pathology.
About the Authors
P. A. Voronchikhin
ГБОУ ВПО СПХФА, Санкт-Петербург
Russian Federation
Russian Federation
M. A. Syrtcova
ГБОУ ВПО СПХФА, Санкт-Петербург
Russian Federation
Russian Federation
S. V. Talantov
ФГК ВОУ ВПО «Военно-медицинская академия им. Кирова», Санкт-Петербург
Russian Federation
Russian Federation
I. L. Erokhina
ФГБУ науки «Институт цитологии РАН», Санкт-Петербург
Russian Federation
Russian Federation
D. E. Korzhevskiy
ФГБУ «НИИ экспериментальной медицины» СЗО РАМН, Санкт-Петербург
Russian Federation
Russian Federation
E. G. Sukhorukova
ФГБУ «НИИ экспериментальной медицины» СЗО РАМН, Санкт-Петербург
Russian Federation
Russian Federation
S. V. Okovitiy
ГБОУ ВПО СПХФА, Санкт-Петербург
Russian Federation
Russian Federation
A. V. Kulikov
ГБОУ ВПО СПХФА, Санкт-Петербург
Russian Federation
Russian Federation
References
1. Ворончихин П.А. Модифицированная модель бронхиальной астмы у аутбредных крыс / Сб. науч. тр. по материалам II всероссийской науч. конф. «Проблемы биомедицинской науки третьего тысячелетия» // Медицинский академический журнал. 2012. Приложение. С. 114-116.
2. Коржевский Д.Э., Григорьев И.П., Отеллин В.А. Применение обезвоживающих фиксаторов, содержащих соли цинка, в нейрогистологических исследованиях // Морфология. 2006. Т. 129. № 1. С. 85-86.
3. Рабочая группа Европейского общества кардиологов по бета-блокаторам. Документ о соглашении экспертов по блокаторам.-адренергических рецепторов // Кардиоваскулярная терапия и профилактика. 2005. № 1. С. 99-124.
4. Barnes P.J. Beta-adrenoceptors on smooth muscle, nerves and inflammatory cells // Life Sci. 1993. Vol. 52. № 26. P. 2101-2109.
5. Barnes P.J. Scientific rationale for combination inhalers with a long-acting.2-agonists and corticosteroids // Eur. Respir. J. 2002. Vol. 19. P. 182-191.
6. Broadley K.J. Beta-adrenoreceptorresponses of the airways: for better or worse // Eur. J. Pharmacol. 2006. Vol. 533. № 13. P. 15-27.
7. Callaerts-Vegh Z., Evans K.L.J., Dudekula N., et al. Effects of acute and chronic administration of.-adrenoreceptors ligands on airwayfunction in a murine model of asthma // PNAS. 2004. Vol. 101. № 14. P. 49494953.
8. Dunn T.L., Gerber M.J., Shen A.S., et al. The effect of topical ophalmic instillation of timolol and betaxolol on lung function in asthmatic subjects // Am. Rev. Respir. Dis. 1986. Vol. 133. № 2. P. 264-268.
9. Haney S., Hancox R.J. Tolerance to bronchodilation during treatment with long-acting beta-agonists, a randomised controlled trial // Respir. Res. 2005. Vol. 6. P. 107.
10. Kamachi A., M. Munakata, Y. Nishimura, et al. Enhance of goblet cell hyperplasia and airwayhyperresponsiveness by salbutamol in a rat model of atopic asthma // Thorax. 2001. Vol. 56. P. 19-24.
11. Khafagi F.A., Shapiro B., Fig L.M., et al. Labetalol reduces iodine-131-MIBG uptake by pheochromocytoma and normal tissues // J. Nucl. Med. 1989. Vol. 30. P. 481-489.
12. Lin R., Peng H., Nguyen L.P., et al. Changes in.2-adrenoreceptor and other signaling proteins produced by chronic administration of «.-blockers» in a murine asthma model // Pulmonary Pharmacology and therapeutics. 2008. Vol. 21. P. 115-127.
13. Masuda T., Tanaka H., Komai M., et al. Mast cells play a partial role in allergen-induced subepithelial fibrosis in a murine model of allergic asthma // Clin. Exp. Allergy. 2003. Vol. 33. № 5. P. 705-713.
14. Nelson H.S., Weiss S.T., Bleecker E.R., et al. The salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol // Chest. 2006. Vol. 129. № 1. P. 15-26.
15. Nguyen L.P., Omoluabi O., Parra S. Chronic exposure to beta-blockers attenuates inflammation and mucin contant in a murine asthma model // Am. J. Respir. Cell and Mol. Biol. 2008. Vol. 65. P. 256-261. Биомедицина № 2, 2013 50 Влияние метопролола и бисопролола на течение экспериментальной бронхиальной астмы
16. Nguyen L.P., Singh B., Okulate A.A., et al. Complementary anti-inflammatory effects of a.-blocker and a corticosteroid in an asthma model // NaunynSchmiedeberg's Arch. Pharmacol. 2012. Vol. 2. № 385. P. 203-210.
17. Reiter M.J. Cardiovascular drug class specificity:.-blockers // Progress in Cardiovas. Dis. 2004. Vol. 47. № 1. P. 11-33.
18. Salmon M., Walsh D.A., Koto H. Repeatead allergen exposure of sensitized Brown — Norway rats induces airway cell DNA synthesis and remodeling // Eur. Respir. J. 1999. Vol. 14. P. 633-641.
19. Singh B.N., Whitlock R.M., Comber R.H., et al. Effects of cardioselective beta adrenoreceptor blockade on specific airways resistance in normal subjects and in patients with bronchial asthma // Clin. Pharmacol. Ther. 1976. Vol. 19. P. 493-501.
20. Solanki K.K., Bomanji J., Moyes J., et al. A pharmacological guide to medicines which interfere with the biodistribution of radiolabelled metaiodobenzylguanidine (MIBG) // Nucl. Med. Commun. 1992. V. 13. P. 513-521.
21. Spitzer W.O., Suissa S., Ernst P., Horwitz R.I., Habbick B., et al. The use of beta-agonists and the risk of death and near death from asthma // The new England Journal of medicine. — 1992. Vol. 326. № 8. P. 501-506.
22. Taylor D.R., Town G.I., Herbison G.P., et al. Asthma control during longterm treatment with regular inhaled salbutamol and salmeterol // Thorax. 1998. Vol. 53. № 9. P. 744-752.
23. Tohda Y., Muraki M., Kubo H., et al. Role of chemical mediators in airway hyperresponsiveness in an asthmatic model // Respiration. 2001. V. 68. № 1. P. 73-77.
24. Tsuchiya T., Nishimura Y., Nishiuma T., et al. Airway remodeling of murine chronic antigen exposure model // J. Asthma. 2003. Vol. 40. № 8. P. 935-944.
25. Vos T., Flaxman A.D., Naqhavi M., Lozano R., et al. Years lived with disability (YLDs) for 1160 sequelae of 289 disease and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 // Lancet. 2012. Vol. 380. P. 9859.
Review
For citations:
Voronchikhin P.A., Syrtcova M.A., Talantov S.V., Erokhina I.L., Korzhevskiy D.E., Sukhorukova E.G., Okovitiy S.V., Kulikov A.V. Effect of metoprolol and bisoprolol on the course of experimental bronchial asthma. Journal Biomed. 2013;1(2):42-51. (In Russ.)
Views:
603
Email this article 
