Изменения релейных и пластических свойств глутаматергических синапсов в прелимбической коре крыс при поведенческой депрессии
Аннотация
Data about a prefrontal cortex activity particularly it prelimbic division at conditions of depressive syndrome are controversial. Sources of discrepancies are different syndrome duration or registration of activity in cortex superficial or deep layers. We evoked behavioral depression by chronic inflammation of back skin or by decreasing of monoamine levels in brain after reserpine administration in experiments on rats. It was explored the glutamatergic synaptic transmission at 2/3 and 5 layers of prelimbic cortex on brain slices of rats with depressive syndrome. The most significant alterations of synaptic transmission at 2/3 layers at condition of behavioral depression are increasing of amplitudes of NMDA component of field EPSPs and inhibition of long-term potentiation expression. In 5 layer of cortex it was detected decreasing amplitudes of field EPSPs for account of inhibition its AMPA components and inhibition of long-term potentiation expression. It may be to think that decreasing of activity of output neurons of 5 layer of medial prefrontal cortex and violation of connection of cortex with limbic structures bases of depressive syndrome.
Об авторах
И. И. Абрамец
Донецкий национальный медицинский университет им. М. Горького
Россия
Россия
Д. В. Евдокимов
Донецкий национальный медицинский университет им. М. Горького
Россия
Россия
Т. О. Зайка
Донецкий национальный медицинский университет им. М. Горького
Россия
Россия
Список литературы
1. Абрамец И.И., Евдокимов Д.В., Талалаенко А.Н. Изменения пластических свойств и метапластичности глутаматергических синапсов в коре и гиппокампе крыс при резерпиновой поведенческой депрессии // Нейрофизиология. 2007. Т. 39. № 3. С. 214-221.
2. Тринус Ф.П., Мохорт Н.А. Нестероидные противовоспалительные средства. - Киев: Здоровье. 1975. С. 218.
3. Covington H.E., Lobo M.K., Maze I., et al. Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex // J. Neurosci. 2010. V. 30. No. 48. P. 16082-16090.
4. Etkin A. Functional neuroanatomy of anxiety: a neural circuit perspective // Curr. Top. behav. neurosci. 2010. V. 2. No. 3. P. 251-277.
5. Goldwater D.S., Pavlides C., Hunter R.G., et al. Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery // Neuroscience. 2009. V. 164. No. 2. P. 798-808.
6. Hamani C., Mayberg H., Stone S., et al. The subcallosal cingulate gyrus in the context of major depression // Biol. Psychiatry. 2011. V. 69. No. 4. P. 301-308.
7. Handley S.L., Mithani S. Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration of “fear”-motivated behavior // Naunyn-Smiedebergs Arch. Pharmacol. 1984. V. 327. No. 1. P. 1-5.
8. Haro J., Oreland L. Depression as spreading adjustment disorder of monoaminergic neurons: a case for primary implications of the locus coeruleus // Brain Res. Rev. 2001. V. 38. No. 1. P. 79-128.
9. Holtzheimer P.E., Mayberg H.S. Deep brain stimulation for psychiatric disorders // Annu. Rev. Neurosci. 2011. V. 34. P. 289-307.
10. Krishnan V., Nestler E.J. Animal models of depression: molecular perspectives // Curr. Top. behav. neurosci. 2011. V. 7. No. 2. P. 121-147.
11. Kumar S., Black S.J., Hultman R., et al. Cortical control of affective networks // J. Neurosci. 2013. V. 33. No. 3. P. 1116-1129.
12. Mathew S.J., Manji H.K., Charney D.S. Novel drugs and therapeutic targets for severe mood disorders // Neuropsychopharmacol. 2008. V. 33. No. 9. P. 2080-2092.
13. Mayberg H.S., Lozano A.M., Voon V., et al. Deep brain stimulation for treatment resistant depression // Neuron. 2005. V. 45. No. 2. P. 651-660.
14. Metz A.E., Yau H.-J., Centeno M.V., et al. Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain // Proc. Nat. Acad. Sci. USA. 2009. V. 108. No. 7. P. 2423-2428.
15. Milad M.R., Quirk G.J. Neurons in medial prefrontal cortex signal memory for fear extinction // Nature. 2002. V. 420. No. 6911. P. 70-74.
16. Olfe J., Domanska G., Schuett C., et al. Different stress-related phenotypes of BALB/c mice from in-house or vendor: alteration of the symapathetic and HPA axis responsiveness // BMC Physiology. 2010. V. 10. No. 2. P. 2-11.
17. Porsolt R.D., Bertin A., Jalfre M. “Behavioural despair” in rats and mice: strain differences and effects of imipramine // Eur. J. Pharmacol. 1978. V. 51. No. 2. P. 291-294.
18. Price J.L., Drevets W.C. Neural circuits underlying the pathophysiology of mood disorders // Trends Cogn. Sci. 2012. V. 16. No. 1. P. 61-71.
19. Riga M., Matos M.R., Glas A., et al. Optogenetic dissection of medial prefrontal cortex circuitry // Frontiers Syst. Neurosci. 2014. V. 8. Article 230; doi 10 3389/fnsys.2014.00230.
20. Salvadore G., Cornwell B.R., Sambataro F., et al. Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine // Neuropsychopharmacol. 2010. V. 35. No. 7. P. 1415-1422.
21. Vezzani A., Viviani B. Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability // Neuropharmacol. 2015. V. 96. No. 1. P. 70-82.
22. Warden M.R., Selimbeyoglu A., Mirzabekov J.J., et al. A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge // Nature. 2012. V. 492. No. 7429. P. 428-432.
23. Yizhar O., Fenno L.E., Prigge M., et al. Neocortical excitation/inhibition balance in information processing and social dysfunction // Nature. 2011. V. 477. No. 7363. P. 171-178.
24. Zarate C.A., Singh J.B., Carlson P.J., et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression // Arch. Gen. Psychiatry. 2006. V. 63. No. 4. P. 856-864.
25. Zoladz P.R., Munos C., Diamond D.M. Beneficial effects of tianeptine on hippocampus-dependent long-term memory and stress-induced alterations of brain structure and function // Pharmaceuticals. 2010. V. 3. P. 3143-3166; doi: 10 3390/ph 3103143.
Для цитирования:
Абрамец И.И., Евдокимов Д.В., Зайка Т.О. Изменения релейных и пластических свойств глутаматергических синапсов в прелимбической коре крыс при поведенческой депрессии. БИОМЕДИЦИНА. 2016;(2):22-31.
For citation:
Abramets I.I., Evdokimov D.V., Zayka T.O. The alterations of relay and plasticity properties of glutamatergic synapses within prelimbic cortex of rats at conditions the behavioral depression. Journal Biomed. 2016;(2):22-31. (In Russ.)
Просмотров: 53
Послать статью по эл. почте 