The significance of ABCB1 gene C3435T polymorphism study for the evaluation of benefit/risk beta-blockers treatment in Russian pregnant women with chronic hypertension
Abstract
Objectives were to determine whether C3435T polymorphism in ABCB1 gene is associated with efficacy and safety of bisoprolol treatment in Russian pregnant women with mild to moderate chronic hypertension. The comparative analysis of allele/genotype frequencies of ABCB1 gene C3435T polymorphism was undertaken in Russian pregnant women with mild to moderate chronic hypertension (N1=65) and healthy subjects on the similar periods of gestation (N2=86). The data suggest that C3435T polymorphism in ABCB1 gene is not associated with efficacy of bisoprolol treatment. The maternal ABCB1/C3435T polymorphism showed association with birth weight and Apgar score.
About the Authors
E. A. Sokova
Центр клинической фармакологии ФГБУ НЦЭСМП Минздрава России, Москва
Russian Federation
Russian Federation
V. G. Kukes
Центр клинической фармакологии ФГБУ НЦЭСМП Минздрава России, Москва
Russian Federation
Russian Federation
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Review
For citations:
Sokova E.A., Kukes V.G. The significance of ABCB1 gene C3435T polymorphism study for the evaluation of benefit/risk beta-blockers treatment in Russian pregnant women with chronic hypertension. Journal Biomed. 2014;1(2):119-127. (In Russ.)
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