Experimental and clinical analysis of comparative Valdoxan and Fluoxetine influence on pharmaco-EEG parameters
Abstract
The problem of competent depression diagnostics and treatment in medical practice is quite obvious and actual. In this case pharmaco-EEG represents one of the most reliable methods of pharmacotherapy efficiency assessment. We’ve analysed cerebral EEG rhythms distribution character in conditions of experimental depression in rats, including antidepressants (Valdoxan and Fluoxetine) usage. It was established that antidepressants induces animals exploration activity increase, as well as significant potentiation of normally dominating EEG theta-rhythm activity in rats. The similar EEG-rhythm distribution analysis was carried out in patients with depression, including the period of Valdoxan and Fluoxetine pharmacotherapy. It is noted that antidepressants usage significantly improves current condition, inducing normal distribution of alpha-rhythm and reduction of slow-wave activity on EEG.
Keywords
About the Authors
O. M. Kudelina
ГБОУ ВПО Ростовский государственный медицинский университет, Ростов-на-Дону
Russian Federation
Russian Federation
V. B. Nazarov
ГБОУ ВПО Ростовский государственный медицинский университет, Ростов-на-Дону
Russian Federation
Russian Federation
Yu. S. Maklyakov
ГБОУ ВПО Ростовский государственный медицинский университет, Ростов-на-Дону
Russian Federation
Russian Federation
D. P. Khloponin
ГБОУ ВПО Ростовский государственный медицинский университет, Ростов-на-Дону
Russian Federation
Russian Federation
V. G. Zaika
ГБОУ ВПО Ростовский государственный медицинский университет, Ростов-на-Дону
Russian Federation
Russian Federation
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Review
For citations:
Kudelina O.M., Nazarov V.B., Maklyakov Yu.S., Khloponin D.P., Zaika V.G. Experimental and clinical analysis of comparative Valdoxan and Fluoxetine influence on pharmaco-EEG parameters. Journal Biomed. 2015;1(1):24-35. (In Russ.)
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