Selection of conditions and criteria of an estimation of biological activity and specificity of Purified Allergen of atypical mycobacterium

Abstract

According to the International Documentation requirements of the parameters and the criteria of the biological activity estimation and specificity of Purified Allergen of atypical mycobacterium weve found out. The expediency of definition of size biological activity of Purified Allergen of atypical mycobacterium on the guinea pigs infected with mixture of mycobacteria M. intracellularae and M. scrofulaceum is shown. It is shown, that the definition of a parameter of Purified Allergen of atypical mycobacterium requires to carry out the specificity of the allergen on guinea pigs infected with a mixture of mycobacterium M. intracellularae and M. scrofulaceum and the guinea pigs infected M. bovis . The main point of the research consists of in the development of biological models and selection of dozes of Purified Allergen of atypical mycobacterium for the definition of size biological activity and specificity.