Microfluidic technologies in studying and modelling the blood-brain barrier
Abstract
Development of the blood-brain barrier model in vitro is one of the main points in modern Neurobiology and Neuropharmacology. Application of microfluidic approach to the blood-brain barrier modeling allows studying and reconstructing the key events in cerebral angiogenesis, barriergenesis, regulation of structural and functional integrity of the barrier, and testing the drug candidates targeting brain tissue. Here we review the current achievements in the development of blood-brain barrier microfluidic models as well as the most promising technological solutions to get novel opportunities in the development and application of these models in vitro .
About the Authors
A. V. Morgun
НИИ молекулярной медицины и патобиохимии ФГБОУ ВО «Красноярский государственный медицинский университет имени проф. В.Ф. Войно-Ясенецкого» Минздрава России, Красноярск
Russian Federation
Russian Federation
V. V. Salmin
НИИ молекулярной медицины и патобиохимии ФГБОУ ВО «Красноярский государственный медицинский университет имени проф. В.Ф. Войно-Ясенецкого» Минздрава России, Красноярск
Russian Federation
Russian Federation
Y. A. Uspenskaya
НИИ молекулярной медицины и патобиохимии ФГБОУ ВО «Красноярский государственный медицинский университет имени проф. В.Ф. Войно-Ясенецкого» Минздрава России, Красноярск
Russian Federation
Russian Federation
E. A. Teplyashina
НИИ молекулярной медицины и патобиохимии ФГБОУ ВО «Красноярский государственный медицинский университет имени проф. В.Ф. Войно-Ясенецкого» Минздрава России, Красноярск
Russian Federation
Russian Federation
A. B. Salmina
НИИ молекулярной медицины и патобиохимии ФГБОУ ВО «Красноярский государственный медицинский университет имени проф. В.Ф. Войно-Ясенецкого» Минздрава России, Красноярск
Russian Federation
Russian Federation
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Review
For citations:
Morgun A.V., Salmin V.V., Uspenskaya Y.A., Teplyashina E.A., Salmina A.B. Microfluidic technologies in studying and modelling the blood-brain barrier. Journal Biomed. 2016;(4):22-33. (In Russ.)
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