Comparative analysis of singe nucleotide polymorphisms of gene IL28B in Russian and Tyvinian patients with hepatitis C

The aim of the study was to detect single nucleotide polymorphisms (SNP) near gene IL28B on locus rs12979860 (С>T) and locus rs8099917 (T>G), which are prognostically significant for standard dual therapy in patients with chronic hepatitis C of Russian (Europian) and Tyvinian (Mongoloid) ethnicity. The SNP were discovered by real-time PCA. The Tyvinian patients more frequency showed the C-allele, and Russian patients more frequency displayed Т-allele (p=0.0466). There were no differences in T- and G-alleles on locus rs8099917. The Tyvinian patients more often showed genotype C/C (p=0.0231) and Russian patients more frequency displayed genotype C/Т (p=0.0425) on locus rs1297960. Genotype T/T on locus rs8099917 significantly often detected in Tyvinian patients (p=0.0259) and genotype T/G more frequently detected in Russian patients (p=0.0188). When take in account two polymorphic loci, genotype С/С (rs12979860) - Т/Т (rs8099917) significantly often detected in Tyvinian patients (p=0.0203), this genotype is associated with more ability to get sustained virologic response.

однонуклеотидный полиморфизм, ген IL28B, гепатит С, этногенетические различия, singe nucleotide polymorphisms, gene IL28B, hepatitis C, ethno-genetic differences

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