Evaluation of the safety of long-term use of the drug KLS-073 as incretinomimetics

During this work it was studied the influence of the new entretenimiento of natural origin (DPP-4 inhibitor, the drug KLS-073) on basic biochemical parameters for a long period (12 months) of application. The experiment was carried out on outbred mice of both sexes. The introduction of the drug was carried out during 12 months in three doses: higher therapeutic (ITD) (2 mg/kg), 5 ITD (10 mg/kg) and 10 ITD (20 mg/kg). As of the evaluation criteria in the assessment we used overall biochemical and hematological parameters and histological examination of the thyroid and the pancreas over time (the 31st, the 91st, 181st and 361 th days). According to the results, the study showed no differences in biochemical parameters and structure of the thyroid and pancreas glands of intact animals and animals treated with the study drug KLS-073.

дипептидипептидаза 4, инкретиномиметики, КЛС-073, комплекс из гонад морских ежей, S. Droebachiensis, dipeptidylpeptidase 4, incretinomimetics, KLS-073, a complex of gonads of sea urchins, S. Droebachiensis

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