Analysis of nebivolol cardioprotective effect on myocardium ultrastructure during regenerative & plastic heart failure in rats
Abstract
Long-tern course of treatment with an antracycline antibiotic adriamycin induces a pronounced cardio-
toxic reaction with a development of specific manifestations of regenerative & plastic heart failure in rats.
Cardioselective β1-blocker nebivolol reveals evident cardioprotective activity in this heart failure model. It's
confirmed by a considerable reduction of cardiomyocytes cell death processes intensity (mainly apoptosis),
delayed activation of intracellular regeneration signs in the majority of heart muscle cells, structural stabi-
lization of myohematic barrier components, and reduction of intracellular and especially interstitial edema
manifestations.
toxic reaction with a development of specific manifestations of regenerative & plastic heart failure in rats.
Cardioselective β1-blocker nebivolol reveals evident cardioprotective activity in this heart failure model. It's
confirmed by a considerable reduction of cardiomyocytes cell death processes intensity (mainly apoptosis),
delayed activation of intracellular regeneration signs in the majority of heart muscle cells, structural stabi-
lization of myohematic barrier components, and reduction of intracellular and especially interstitial edema
manifestations.
About the Authors
Ю. Кротова
Ростовский государственный медицинский университет, Ростов-на-Дону
Russian Federation
Russian Federation
Д. Хлопонин
Ростовский государственный медицинский университет, Ростов-на-Дону
Russian Federation
Russian Federation
П. Хлопонин
Ростовский государственный медицинский университет, Ростов-на-Дону
Russian Federation
Russian Federation
Т. Архипова
Ростовский государственный медицинский университет, Ростов-на-Дону
Russian Federation
Russian Federation
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, , , Analysis of nebivolol cardioprotective effect on myocardium ultrastructure during regenerative & plastic heart failure in rats. Journal Biomed. 2012;1(1):86-92. (In Russ.)
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