Investigation of the effects of new synthetic peptide - derivative of ApoE COG1410 on the behavior and brain morphology of CD rats subjected to focal stroke
Abstract
Using model of focal brain ischemia in males of CD rats, neuroprotective properties of peptide COG1410,
with sequence of ApoE receptor-binding domen were investigated. Brain ischemia was performed by
intralumenal occlusion of middle cerebral artery with further reperfusion. Peptide was injected intravenously
30 minutes after reperfusion. For 35 days the coordination and balance of animals, and also locomotor
asymmetry were tested. In the serial slices of brain, the infarction volume was calculated. Animals, treated
with COG1410, showed reliable improvement of motor functions and reduction of infarction volume of the
affected hemisphere.
with sequence of ApoE receptor-binding domen were investigated. Brain ischemia was performed by
intralumenal occlusion of middle cerebral artery with further reperfusion. Peptide was injected intravenously
30 minutes after reperfusion. For 35 days the coordination and balance of animals, and also locomotor
asymmetry were tested. In the serial slices of brain, the infarction volume was calculated. Animals, treated
with COG1410, showed reliable improvement of motor functions and reduction of infarction volume of the
affected hemisphere.
About the Authors
Е. Туховская
Филиал института биоорганической химии им. акдемиков М.М. Шемякина и
Ю.А. Овчинникова РАН (ФИБХ)
Russian Federation
Russian Federation
А. Лобанов
Филиал института биоорганической химии им. акдемиков М.М. Шемякина и
Ю.А. Овчинникова РАН (ФИБХ)
Russian Federation
Russian Federation
А. Мурашев
Филиал института биоорганической химии им. акдемиков М.М. Шемякина и
Ю.А. Овчинникова РАН (ФИБХ)
Russian Federation
Russian Federation
References
1. Лебедев С.В. с соавт. // Бюллетень экс- периментальной биологии и медицины. 2003. Том 135. №5. C. 500-504.
2. Aoki K. et al. // Stroke. 2003. V. 34 (4). P. 875-880.
3. Belayev L. et al. // Stroke. 1996. V. 27. P. 1616-1622.
4. Boschert U. et al. // Neurobiol. Dis. 1999. V. 6 (6). P. 508-514.
5. Buttini M. et al. // J. Neurosci. 1999. V. 19 (12). P. 4867-4880.
6. Chen Y. et al.// Neuroscience. 1997. V. 80. P. 1255-1262.
7. Laskowitz D.T. et al..// Acta. Neurol. Scand. 2006. V.114 (Suppl. 185). P. 15-20.
8. Linton M. et al. // J. Clin.Invest. 1991. V. 81. P. 270-281.
9. Lynch J.R. et al. // Ann. Neurol. 2002. V. 51. P. 113-117.
10. Masliah E. et al. // Exp. Neurol. 1995. V. 136 (2). P. 107-122.
11. Pitas R.E. et al. // J. Biol. Chem. 1987. V. 262 (29). P. 14352-14360
12. Poirier J. et al. // Brain. Res. Mol. Brain. Res. 1991. V. 11 (2). P. 97-106.
13. Xu Q. et al.// J. Neurosci. 2006. V. 26 (19). P. 4985-4994.
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, , Investigation of the effects of new synthetic peptide - derivative of ApoE COG1410 on the behavior and brain morphology of CD rats subjected to focal stroke. Journal Biomed. 2012;1(1):99-101. (In Russ.)
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