Influence of gastric acidity on intestinal microflora
- Р Р‡.МессенРТвЂВВВВВВВВжер
- РћРТвЂВВВВВВВВнокласснРСвЂВВВВВВВВРєРСвЂВВВВВВВВ
- LiveJournal
- Telegram
- ВКонтакте
- РЎРєРѕРїРСвЂВВВВВВВВровать ссылку
Full Text:
Abstract
The effect of hypochlorhydria on qualitative and quantitative composition of the luminal microflora in the jejunum and cecum of rats was studied. It is shown that intragastric administration of pariet for 16 days leads to the Escherichia coli colonization of the proximal small intestine, which is accompanied by loss of body weight. It is found a decrease in the composition of microbiota in the jejunum and cecum. Qantitative disappearance of the proximal-distal gradient of microorganisms in the intestine was detected.
About the Authors
N. S. Tropskaya
ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы», Москва
Russian Federation
Russian Federation
I. G. Shashkova
ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы», Москва
Russian Federation
Russian Federation
T. V. Chernen'kaya
ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы», Москва
Russian Federation
Russian Federation
T. S. Popova
ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы», Москва
Russian Federation
Russian Federation
G. D. Kapanadze
ФГБУН «Научный центр биомедицинских технологий ФМБА России», Московская область
Russian Federation
Russian Federation
References
1. Ardatskaya M.D., Minushkin O.N., Ikonnikov N.S. Disbakterioz kishechnika: ponyatie, diagnosticheskie podkhody i puti korrektsii. Vozmozhnosti i preimushchestva biokhimicheskogo issledovaniya kala: posobie dlya vrachei. - M., 2004.
2. Serebrova S.Yu., Dobrovol'skii O.V. Terapiya yazvennoi bolezni i problemy sokhraneniya mikroekologii zheludochno-kishechnogo trakta // Russkii meditsinskii zhurnal. 2007. № 16. S. 1193-1198.
3. Brummer R.J., Stockbrügger R.W. Effect of nizatidine 300 mg at night and omeprazole 20 mg in the morning on 24-hour intragastric pH and bacterial overgrowth in patients with acute duodenal ulcer // Dig. dis. sci. 1996. Vol. 41. No. 10. P. 2048-2054.
4. Diogo Filho A., Santos P.S., Duque A.S., Cezário R.C., Gontijo Filho P.P. Experimental model in the qualitative and quantitative assessment of non-Helicobacter gastric microflora under proton pump inhibitors action // Acta Cir. Bras. 2006. Vol. 21. No. 5. P. 279-284.
5. Gasbarrini A., Lauritano E.C., Garcovich M., Sparano L., Gasbarrini G. New insights into the pathophysiology of IBS: intestinal microflora, gas production and gut motility // Eur. rev. med. pharmacol. sci. 2008. Vol. 12. Suppl. 1. P. 111-117.
6. Lo W., Chan W.W. Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis // Clin. gastroenterol. hepatol. 2013. Vol.11. No. 5. R. 483-490.
7. Shindo K., Machida M., Fukumura M., Koide K., Yamazaki R. Omeprazole induces altered bile acid metabolism // Gut. 1998. Vol. 42. No. 2. P. 266-271.
8. Theisen J., Nehra D., Citron D., Johansson J., Hagen J.A., Crookes P.F., DeMeester S.R., Bremner C.G., DeMeester T.R., Peters J.H. Suppression of gastric acid secretion in patients with gastroesophageal reflux disease results in gastric bacterial overgrowth and deconjugation of bile acids // J. Gastrointest. surg. 2000. Vol. 4. No. 1. P. 50-54.
Review
For citations:
Tropskaya N.S., Shashkova I.G., Chernen'kaya T.V., Popova T.S., Kapanadze G.D. Influence of gastric acidity on intestinal microflora. Journal Biomed. 2016;(4):92-98. (In Russ.)
Views:
316
ISSN 2074-5982 (Print)
ISSN 2713-0428 (Online)
ISSN 2713-0428 (Online)
Email this article 
