Adaptive changes in rats under everyday physical load in «The run on treadmill» method
Abstract
The adaptive changes in rats under 4 week’s everyday training (4 days/week) and test (1 days/week) physical exercise on treadmill was investigated. The training exercise was consisted of 20 minutes run with velocity 15 m/min and incline 15°. The test exercise was 20-30 minutes run until exhaustion with acceleration 0,6 m/min2, initial velocity 12 m/min and incline 15°. The test exercise was corresponded to submaximal intensity aerobic capacity zone, and training exercise was related to medium or low intensity aerobic capacity zone by results of measurements glucose and lactate blood level. The adaptation to load were associated with the muscle hypertrophy, erythrocytes increasing, mean corpuscles volume, red cell width distribution and platelets decreasing, reduction heart rate and values of systolic pressure. The physical exercise did not influence on glucose tolerance and glucose blood level, containing glucose and glycogen in gastrocnemius muscle, wet weight of epididymal fat in rats. After 4 weeks physical load did not influence on left adrenal, thymus and spleen weights, blood level of cortisol, thyroxin, triiodothyronine and urea, liver protein and amino transferases activity, muscle lactate, protein and aspartate amino transferase activity. Therefore we suggested that physical exercise did not produce fatigue in rat.
About the Authors
D. G. Ivanov
ФГУП «НЦ «Сигнал»
Russian Federation
Russian Federation
N. V. Alexandrovskaya
ФГУП «НЦ «Сигнал»
Russian Federation
Russian Federation
E. A. Afonkina
ФГУП «НЦ «Сигнал»
Russian Federation
Russian Federation
P. V. Eroshkin
ФГУП «НЦ «Сигнал»
Russian Federation
Russian Federation
A. N. Semenov
ФГУП «НЦ «Сигнал»
Russian Federation
Russian Federation
D. V. Busiigin
ФГУП «НЦ «Сигнал»
Russian Federation
Russian Federation
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49. Monteiro M.F., Filho D.C.S. Physical exercise and blood pressure control // Rev. bras. med. esporte. 2004. V. 10. No. 6. P. 517-519.
50. Moraska A., Deak T., Spencer R.L., Roth D., Fleshner M. Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats // Am. J. Physiol. regulatory integrative comp. physiol. 2000. V. 279. P. R1321-R1329.
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53. Voltarelli F.A., Gobatto C.A., Mello M.A.R. Determination of anaerobic threshold in rats using the lactate minimum test // Braz. J. med. biol. res. 2002. V. 35. No. 11. P. 1389-1394.
54. Zendzian-Piotrowska M., Gorski J. Metabolic adaptation to daily exercise of moderate intensity to exhaustion in the rat // Eur. J. Appl. physiol. 1993. V. 67. P. 77-82.
Review
For citations:
Ivanov D.G., Alexandrovskaya N.V., Afonkina E.A., Eroshkin P.V., Semenov A.N., Busiigin D.V. Adaptive changes in rats under everyday physical load in «The run on treadmill» method. Journal Biomed. 2017;(2):4-22. (In Russ.)
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