The study of a novel diethylaminoethanol derivative cognitive function in laboratory animals
Abstract
The influence of a novel diethylaminoethanol derivative (10 and 75 mg/kg) was studied in the following tests: conditional reaction of passive avoidance, «Extrapolation deliverance» and «T-maze» tests. FDES had a protective impact on the consolidation and reproduction of memory trace in 2 and 24 hours after scopolamine was administered, and its effect was comparable to that of piracetam. Furthermore, the novel diethylaminoethanol derivative facilitated the retention of the ability to choose the "correct" arm in the T-maze test and also outperformed the reference drug (agent). During the administration of FDES in both doses, in the EP test, the rats dove under the edge of the cylinder earlier, also the number of rats which dove was higher in comparison with rats to which piracetam was administered.
About the Authors
I. A. Titovich
Санкт-Петербургская государственная химико-фармацевтическая академия Минздрава России
Russian Federation
Russian Federation
S. V. Radko
Санкт-Петербургская государственная химико-фармацевтическая академия Минздрава России
Russian Federation
Russian Federation
D. S. Lisitsky
Институт токсикологии Федерального медико-биологического агентства
Russian Federation
Russian Federation
S. V. Okovity
Санкт-Петербургская государственная химико-фармацевтическая академия Минздрава России
Russian Federation
Russian Federation
V. T. Bolotov
Санкт-Петербургская государственная химико-фармацевтическая академия Минздрава России
Russian Federation
Russian Federation
A. V. Belsky
Институт токсикологии Федерального медико-биологического агентства
Russian Federation
Russian Federation
M. V. Mikhailova
Институт токсикологии Федерального медико-биологического агентства
Russian Federation
Russian Federation
I. Y. Sysoev
Санкт-Петербургская государственная химико-фармацевтическая академия Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Titovich I.A., Radko S.V., Lisitsky D.S., Okovity S.V., Bolotov V.T., Belsky A.V., Mikhailova M.V., Sysoev I.Y. The study of a novel diethylaminoethanol derivative cognitive function in laboratory animals. Journal Biomed. 2017;(3):102-110. (In Russ.)
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