Long-term effects of stem cells on irradiated mice
Abstract
C57Bl/6Y mice were exposed to gamma-radiation in a sublethal dose of 7.5 Gy. In 3 hours injection 106/mouse of bone marrow multipotent mesenchymal stromal cells intravenously to experimental group was done. Methods used: body weight measurement, «open field» behavior, subfraction composition of blood serum (laser correlation spectroscopy), histological examination of the spleen, liver, and pancreas, count of T- and B- cells (cytometry), white blood formula. After 1.5 and 3 months the general trend towards intermediate position of the parameters observed in the experimental between those in intact and irradiated controls attests to partial therapeutic effect of the injected cells.
About the Authors
M. V. Vyalkina
ФГБНУ «НИИ общей патологии и патофизиологии»
Russian Federation
Russian Federation
I. B. Alchinova
ФГБНУ «НИИ общей патологии и патофизиологии»
Russian Federation
Russian Federation
E. N. Yakovenko
ФГБНУ «НИИ общей патологии и патофизиологии»
Russian Federation
Russian Federation
Yu. S. Medvedeva
ФГБНУ «НИИ общей патологии и патофизиологии»
Russian Federation
Russian Federation
I. N. Saburina
ФГБНУ «НИИ общей патологии и патофизиологии»
Russian Federation
Russian Federation
M. Yu. Karganov
ФГБНУ «НИИ общей патологии и патофизиологии»
Russian Federation
Russian Federation
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Review
For citations:
Vyalkina M.V., Alchinova I.B., Yakovenko E.N., Medvedeva Yu.S., Saburina I.N., Karganov M.Yu. Long-term effects of stem cells on irradiated mice. Journal Biomed. 2017;(4):18-33. (In Russ.)
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