Особенности системы биотрансформации лекарственных средств в фетоплацентарном комплексе
Аннотация
ции экспрессии ферментов I и II фазы системы биотрансформации ксенобиотиков у плода
и в плаценте. В настоящее время понимание и знание метаболизма лекарственных средств
в материнско плацентарно плодном комплексе, факторов, оказывающих влияние на эти
процессы, имеет первостепенное значение в оценке соотношения польза/риск примене
ния лекарственных средств как для материнского организма, так и для плода на протяже
нии всей беременности.
Ключевые слова
Список литературы
1. Кукес В.Г. Метаболизм лекарственных средств: клинико фармакологические ас пекты. - М.: Реафарм, 2004.
2. Сычев Д.А., Раменская Г.В., Игнатьев И.В., Кукес В.Г. Клиническая фармакогенетика: Учебное пособие. - М.: ГЭОТАР Медиа, 248 с., 2007.
3. Anderson G.D. Pregnancy induced changes in pharmacokinetics: a mechanistic based ap proach // Clin. Pharmacokinet. - 44(10):989 1008, 2005.
4. Bernier F., Leblanc G., Labrie F. et al. The struc ture of human estrogen and aryl sulphotrans ferase gene: two mRNA species issued from a single gene // J. Biol. Chem. - 269: 28200 5, 1994.
5. Briggs G.G., Freeman R.K., Yaffe S.J. A reference guide to fetal and neonatal risk. Drugs in pregnancy and lactation. Seventh Edition - Lippincott Williams&Wilkins. - Philadelphia, 2005
6. Burchell B., Coughtrie M., Jackson M. et al. Development of human liver UDP glucuro nosyltransferase // Dev. Pharmacol. Ther. -13: 70 7, 1998.
7. Cappiello M., Giuliani L., Rane A. et al. Dopamine sulphotransferase is better developed than p nitrophenol sulphotransferase in human fetusm //Dev. Pharmacol. Ther., 83 8, 1991.
8. Collier A.C., Tingle M.D., Keelan J.A. et al. A highly sensitive fluorescent microplate method for the determination of UDP glucuronosyl transferase activity in tissues and placental cell lines // Drug Metab. Dispo.s, 28: 1184 6, 2000.
9. Collier A.C., Ganley N.A., Tingle M.D. et al. UDP glucuronosyltransferase activity, expres sion and cellular localization in human placenta at term // Biochem. Pharmacol., 63: 409 19, 2002.
10. Collier A.C., Tingle M.D., Paxton J.W. et al. Metabolizing enzyme localisation and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption // Hum. Reprod., 17:2564 72, 2002.
11. Ganley N. The expression and localisation of uridine diphosphate glucuronosyltransferase 2B subfamily in human placenta tissue [M.Sc. thesis]. - Auckland: University of Auckland, 2001.
12. Gilham D.E., Cairns W., Paine M.I.J. et al. Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization // Xenobiotica, 27: 111 25, 1997.
13. Glatt H., Boeing H., Engelke C.E. Human cytosolic sulphotransferases: genetics, charac teristics, toxicological aspects // Mutat. Res., 482: 27 40, 2001.
14. Gu J., Su T., Chen Y. et al. Expression of biotransformation enzymes in human fetal olfactory mucosa: Potential roles in develop mental toxicity // Toxicol. Appl. Pharmacol., 165: 158 162, 2000.
15. Gurtoo H.L., Williams C.I., Gottlieb K. et al. Population distribution of benzo(a)pyrene metabolism in smokers // Int. J. Cancer, 31: 385 95, 1983.
16. Hakkola J., Pasanen M., Hukkanen J. et al. Expression of xenobiotic metabolising cyto chrome P450 forms in human full term placen ta // Biochem. Pharmacol., 51: 403 11, 1996.
17. Hakkola J., Raunio H., Purkunen R. et al. Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnan cy // Biochem. Pharmacol., 52:379 83, 1996.
18. Hakkola J., Pasanen M., Pelkonen O. et al. Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells // Carcinogenesis, 18:391 7, 1997.
19. Hein D.W., Doll M.A., Fretland A.J. et al. Mole cular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms // Cancer Epidemiol. Biomarkers Prev., 9:29 42, 2000.
20. Hincal F. Effects of exposure to air pollution and smoking on the placental aryl hydrocarbon hydroxylase (AHH) activity // Arch. Environ. Health, 41:377 83, 1986.
21. Hines R.N., McCarver D.G. The ontogeny of human drug metabolizing enzymes: phase I oxidative enzymes // J. Pharmacol. Exp. Ther., February 1, 300(2):355 360, 2002.
22. Koskela S., Hakkola J., Hukkanen J. et al. Ex pression of CYP2A genes in human liver and extrahepatic tissues // Biochem Pharmacol, 57:1407 13, 1999.
23. Koukouritaki S.B., Simpson P., Yeung C.K. et al. Human hepatic flavin containing monooxy genase 1 (FMO1) and 3 (FMO3) developmental expression // Pediatr. Res., 50: 1 7, 2002.
24. Koukouritaki S.B., Manro J.R., Marsh S.A. et al. Developmental Expression of human hepatic CYP2C9 and CYP2C19 // J. Pharmacol. Exp. Ther., 308:965 974, 2004.
25. Ladona M.G., Lindstrцm B., Thyr C. et al. Differential foetal development of the O and N demethylation of codeine and dextrometh orphan in man // Br. J. Clin. Pharmacol., 32:295 302, 1991.
26. Mackenzie P., Owens I., Burchell B. et al. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence // Pharmacogenetics, 7:255 69, 1997.
27. McCarver D.G., Hines R.N. The ontogeny of human drug metabolizing enzymes: phase II conjugation enzymes and regulatory mecha nisms // J. Pharmacol. Exp. Ther., February 1, 300(2):361 66, 2002.
28. McRobie D.J., Glover D.D., Tracey T.S. Effects of gestational and overt diabetes on human placental cytochromes P450 and glutathione S transferase // Drug Meta.b Dispos., 26:367 71, 1998.
29. Nelson D.R., Kamataki T., Waxman D.J. et al. The P450 superfamily update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature // DNA Cell Biol, 12:1 51, 1993.
30. Omiecinski C.J., Redlich C.A., Costa P. Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction // Cancer Res., 50:4315 432, 1990.
31. Omiecinski C.J., Aicher L., Swenson L. Develop mental expression of human microsomal epoxide hydrolase // J. Pharmacol. Exp. Ther., 269:417 23, 1994.
32. Paakki P., Stockmann H., Kantola M. et al. Maternal drug abuse and human term placental xenobiotic and steroid metabolising enzymes in vitro // Environ. Health Perspect., 108:141 5, 2000.
33. Pacifici G.M., Rane A. Glutathione S transferase in the human placenta at different stages in pregnancy // Drug Metab. Dispos., 9:472 5, 1981.
34. Pacifici G.M., Rane A. Epoxide hydroxylase in human placenta at different stages in pregnan cy // Dev. Pharmacol. Ther., 6: 83 93, 1983.
35. Pacifici G.M., Bencini C., Rane A. Acetyltrans ferases in humans: development and tissue distribution // Pharmacology, 32:283 91, 1986.
36. Parkinson A. Biotransformation of xenobiotics // In Casarett & Doull's Toxicology. The Basic Science of Poisons (Klaassen C.D. ed.), pp. 113 186, McGraw Hill, New York: 1996.
37. Pasanen M., Pelkonen O. Xenobiotic and ster oid metabolising monooxygenases cataylsed by cytochrome P450 and gluta thione S trans ferase conjugations in the human placenta and theft relationships to maternal cigarette smok ing // Placenta, 11:75 85, 1990.
38. Pasanen M., Pelkonen O. The expression and environmental regulation of P450 enzymes in human placenta // Crit. Rev. Toxicol., 24:211 29, 1994.
39. Pasanen M., Helin Martikainen R.L., Pelkonen O. et al. Intrahepatic cholestasis of pregnancy impairs the activity of human placental xenobiotic and steroid metabolising enzymes in vitro // Placenta, 18:37 41, 1997.
40. Pasanen M. The expression and regulation of drug metabolism in human placenta // Adv. Drug Deliv. Rev., 38:81 97, 1999.
41. Pelkonen O., Vähäkangas K., Kärki N.T. et al. Genetic and environmental regulation of aryl hydrocarbon hydroxylase in man: studies with liver, lung, placenta, and lymphocytes // Toxicol. Pathol., 12:256 60, 1984.
42. Pelkonen O., Arvela P., Kärki N.T. 3,4 benzo (a)pyrene and N methylalanine metabolising en zymes in the immature human fetus and placen ta // Acta Pharmacol. Toxicol., 30:385 95, 1971.
43. Pelkonen O., Jouppila P., Kärki N.T. Effect of maternal cigarette smoking in 3,4 benzo (a)pyrene and N methylalanine metabolism in human fetal liver and placenta // Toxicol. Appl. Pharmacol., 23:29 37, 1972.
44. Price N.T., Jakson V.N., Halestrap A.P. Cloning and sequencing of four new mammalian mono carboxylate transporter (MCT) homologues con firms the existence of a transporter family with an ancient past // Biochem. J., 329:321 8, 1998.
45. Rasheed A., Hines R.N., McCarver D.G. Varia tion in human placental CYP2E1: potential risk factor for growth retardation associated with intrauterine alcohol exposure // Alcoholism, 21 (3):53, 1997.
46. Ratge D., Kohse K.P., Steegmuller U. et al. Dis tribution of free and conjugated catecholamines between plasma, platelets and erythrocytes: different effects of intravenous and oral cate cholamine administration // J. Pharmacol. Exp. Ther., 257:232 8, 1991.
47. Scarborough P.E., Ma J., Qu W., Zeldin D.C. P450 subfamily CYP2J and their role in the bio activation of arachidonic acid in extrahepatic tissues // Drug Metab. Rev., 31:205 234, 1999.
48. Schenker S., Yang Y., Mattiuz E. et al. Olan zapine transfer by human placenta // Clin. Exp. Pharmacol. Physiol., 26:691 7, 1999.
49. Shao J., Stapleton P.L., Lin Y.S., Gallagher E.P. Cytochrome P450 and glutathione S transferase mRNA expression in human fetal liver hemato poietic stem cells // Drug Metab. Dispos., 35(1):168 75, 2007.
50. Shiverick K.T., Salafia C. Cigarette smoking and pregnancy I: ovarian, uterine and placental effects // Placenta, 20:265 72, 1999.
51. Sodha R.J., Glover V., Sandler M. Phenol sulphotransferase in human placenta // Bio chem. Pharmacol., 32:1655 7, 1983.
52. Sodha R.J., Schneider H. Sulphate conjugation of beta2 adrenoceptor stimulating drugs by pla telet and placental phenol sulphotransferase //Br. J. Clin. Pharmacol., 17:106 8, 1984.
53. Sonnier M., Cresteil T. Delayed ontogenesis of CYP1A2 in the human liver // Eur. J. Biochem., 251:893 98, 1998.
54. Shimada T., Yamazaki H., Mimura M. et al. Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs // Drug Metab. Dispos., 24:515 22, 1996.
55. Stevens J.C. New perspectives on the impact of cytochrome P450 3A expression for pediatric pharmacology // Drug Discov. Today, May; 11(9 10):440 5, 2006.
56. Strange R.C., Howie A.F., Hume R. et al. The developmental expression of alpha , mu and pi class glutathione S transferases in human liver // Biochim. Biophys. Acta, 993:186 90, 1989.
57. Syme M.R., Paxton J.W., Keelan J.A. Drug trans fer and metabolism by the human placenta // Clin. Pharmacokinet., 43 (8):487 514, 2004.
58. Treluyer J. M., Jacqz Aigrain E., Alvarez F.,Cresteil T. Expression of CYP2D6 in developing human liver // Eur. J. Biochem., 202:583 88, 1991. 59. van Lieshout E.M., Knapen M.F., Lange W.P. et al. Localization of glutathione S transferases alpha and pi in human embryonic tissues at 8 weeks gestational age // Hum. Reprod., 13:1380 6, 1998.
59. Vieira I., Pasanen M., Raunio H. et al. Expres sion of CYP2E1 in human lung and kidney during development and in full term placenta: a differential methylation of the gene is involved in the regulation process // Pharmacol. Toxicol., 83:183 7, 1998.
60. Ward R.M. Drug therapy of the fetus // J. Clin. Pharmacol., 33:780 9, 1993.
61. Wu S., Moomaw C.R., Tomer K.B. et al. Molec ular cloning and expression of CYP2J2, a hu man cytochrome P450 arachidonic acid epoxy genase highly expressed in heart // J. Biol. Chem., 271:3460 8, 1996.
62. Yang H. Y.L., Namkung M.J., Juchau M.R. Expression of functional cytochrome P4501A1 in human embryonic hepatic tissues during organogenesis // Biochem. Pharmacol., 49:717 26, 1995.
Рецензия
Для цитирования:
Сокова Е.А. Особенности системы биотрансформации лекарственных средств в фетоплацентарном комплексе. БИОМЕДИЦИНА. 2008;1(1):14-25.
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