The comparative analysis of influence of cytostatic drugs on genome instability of Drosophila melanogaster
Abstract
Morphometric analysis of Drosophila melanogaster wings revealed various change of wing`s parameters at influence by Methotrexate, Heldanamicine and Mytomicine-C, and similar changes at influence by Etoposide and Cyclophosphane. At a used dose of 2 mkg/kg of the environment of damage like “cutting” on a wing were observed only in case of influence by the Methotrexate. It is possible to assume what exactly the Methotrexate, Mitomicine-S and Geldanamicine cause big genomic instability, judging by indirect indicators.
About the Authors
O. N. Antosyuk
Уральский федеральный университет имени первого президента России Б.Н. Ельцина, Екатеринбург
Russian Federation
Russian Federation
A. M. Marvin
Уральский федеральный университет имени первого президента России Б.Н. Ельцина, Екатеринбург
Russian Federation
Russian Federation
N. A. Marvin
Уральский федеральный университет имени первого президента России Б.Н. Ельцина, Екатеринбург
Russian Federation
Russian Federation
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Review
For citations:
Antosyuk O.N., Marvin A.M., Marvin N.A. The comparative analysis of influence of cytostatic drugs on genome instability of Drosophila melanogaster. Journal Biomed. 2014;1(3):83-91. (In Russ.)
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