NEW BIOMEDICAL TECHNOLOGIES
The lack of adequate methods for identifying the psychotropic properties of various chemical compounds has dramatically hindered the search for new psychoactive substances. The role of β- and γ-rhythms of brain electrograms in the elucidation of mental processes is poorly investigated. On the other hand, even the isolation of the main acting components of psychotropic substances in animal studies for extrapolating to humans presents a challenge. This article is devoted to the aforementioned issues. This research was performed on cats with electrodes that had been stereotactically implanted in different parts of the brain. Since commercial electroencephalographs were not suitable for our purposes, specialized microchip devices were designed at the Scientific Centre for Biomedical Technologies (SCBMT), Russia. As a mathematical instrument, the fast Fourier transform (FFT) algorithm with a window discrete Fourier transform based on Hamming functions was implemented.
Normalization of the FFT-transformed brain electrograms recorded under the influence of doxylamine, xylazine, caffeine, sertraline, phenotropyl was carried out. The suitability of the proposed approach for assessing the pharmacodynamics of the studied substances, which are characterized by a phase character coinciding with the main pharmacokinetic points, is demonstrated. The β- and γ- rhythms are shown to be the most important indicators of the effects of psychotropic substances.
RELEVANT AND ALTERNATIVE BIOMODELLING
METHODS OF BIOMEDICAL RESEARCHES
ISSN 2713-0428 (Online)